16. EVALUATE THE EFFECTIVENESS OF INTRAVENOUS ANESTHESIA WITH KETAMINE COMBINED XYLAZINE FOR EXPERIMENTAL LIMB TRANSPLANTATION SURGERY IN RABBITS
Main Article Content
Abstract
Objective: Study the effect of intravenous anesthesia with Ketamine combined Xylazine for limb transplantation surgery.
Subjects and methods: 30 pairs of rabbits aged from 1 to 2 years old, indicated for limb replantation surgery, were anesthetized intravenously with Ketamine combined Xylazine. Record the results of induction and maintenance doses, heart rate, respiratory rate, and adverse effects.
Results: The induction dose of Ketamine was 5.2 ± 2.8 mg/kg, with Xylazine 1.6 ± 1.2 mg/kg, maintenance dose of Ketamine 5.8±2.6 mg/kg, with Xylazine 1.8±1.5 mg/kg.
Conclusion: Intravenous anesthesia with Ketamine and Xylazine was effective, the changes heart rate and respiratory rate were not statistically significant.
Article Details
Keywords
Rabbit anesthesia, limb transplantation.
References
[2] Jaimie T Shores, Gerald Brandacher, Andrew Lee W.P. Hand and upper extremity transplantation: an update of outcomes in the worldwide experience. Plast Reconstr Surg, Feb 2015, 135 (2): 351-360.
[3] Sanford T.D, Colby E.D. Effect of Xylazine and Ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab Anim Sci, 1980 Jun, 30 (3): 519-23.
[4] Cantwell S.L. Ferret, rabbit, and rodent anesthesia. Vet Clin North Am Exot Anim Pract, 2001 Jan, 4 (1): 169-91
[5] Lipman N.S et al. A comparison of Ketamine/Xylazine and Ketamine/Xylazine/Acepromazine anesthesia in the rabbit. Lab Anim Sci, 1990 Jul, 40 (4): 395-8
[6] Julia Henke, Susanne Astner, Thomas Brill et al. Comparative study of three intramuscular anaesthetic combinations (Medetomidine/Ketamine, Medetomidine/Fentanyl/Midazolam and Xylazine/Ketamine) in rabbits. Vet Anaesth Analg, 2005 Sep, 32 (5): 261-70.
[7] Güneri Atalan, Gültekin Atalan et al. Comparison of Systemic Effects of Midazolam, Ketamine, and Isoflurane Anaesthesia in Rabbits. J Vet Res, 2019 Jun 12, 63 (2): 275-283.
[8] Lea J Sayce, Maria E Powell et al. Continuous Rate Infusion of Ketamine Hydrochloride and Dexmedetomidine for Maintenance of Anesthesia during Laryngotracheal Surgery in New Zealand White Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci, 2020 Mar 1, 59 (2): 176-185.
[9] McGill. Standard operating procedure rabbit anesthesia. https://www.mcgill.ca/research/files/research/114-rabbit anesthesia-jan 2021.pdf
[10] Muhammad Ali Khan, Ahmed Nawaz Tunio et al. Comparative study of isoflurane and Ketamine anesthetics in Rabbits. Pure Appl. Biol., June 2019, 8 (2): 1385-1397.