17. STEM CELL APPLICATION IN INFERTILITY TREATMENT
Main Article Content
Abstract
Infertility is a reproductive health problem that affects the lives of many wives. The current world infertility rate is about 15%. Current assisted reproductive technologies can solve the problem in most cases. However, there are still a significant number of couples who are unable to conceive even after assisted reproduction is available. In such cases, stem cell therapy can offer hope to couples who wish to have children who are media similar to them. Extensive research is underway on induced pluripotent stem cells (iPSCs). Similarly, mesenchymal stem cells (MSCs) such as skeleton, adipose tissue, menstrual blood, endometriosis, slurry, and placenta, are gaining popularity for application in reproductive medicine. However, more large-scale clinical trials are needed for evidence of the safety and efficacy of stem cell-based therapies in the field of human reproduction.
Article Details
Keywords
infertility, assisted reproduction, stem cells.
References
[1] Shapiro A, Kashani B, Seungdamrong A. Oral Ovulation Induction Agents. 2017, 37(13): 1-7.
[2] Manshadi MD, Navid S, Hoshino Y, Daneshi E, Noory P, Abbasi M. The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure. 2019, 82(6): 635-42.
[3] Zheng SX, Wang J, Wang XL, Ali A, Wu LM, Liu YS. Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells. Int J Mol Med, 2018, 41(4): 2201-12.
[4] Yan Z, Guo F, Yuan Q, Shao Y, Zhang Y, Wang H, et al. Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway. Stem Cell Res Ther, 2019, 10(1): 4.
[5] Zhao YA-O, Chen SA-O, Su PA-O, Huang FA-O, Shi YC, Shi QA-O, et al. Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases. Stem Cells Int, 2019: 9071720.
[6] Xie QA-O, Xiong XA-O, Xiao N, He K, Chen M, Peng J, et al. Mesenchymal Stem Cells Alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by Inhibiting Inflammation in Mice. Stem Cells Int, 2019, (1687-966X (Print)): 9782373.
[7] Xu L, Ding L, Wang L, Cao Y, Zhu H, Lu J, et al. Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars. Stem Cell Res Ther, 2017, 18(1): 84.
[8] Fan D, Wu S Fau - Ye S, Ye S Fau - Wang W, Wang W Fau - Guo X, Guo X Fau - Liu Z, Liu Z. Umbilical cord mesenchyme stem cell local intramuscular injection for treatment of uterine niche: Protocol for a prospective, randomized, double-blinded, placebo-controlled clinical trial. Medicine (Baltimore), 2017, 96(44): e8480.
[9] Damous LL, Nakamuta JS, Carvalho AE, Carvalho KC, Soares JM, Jr., Simões Mde J, et al. Does adipose tissue-derived stem cell therapy improve graft quality in freshly grafted ovaries? Reprod Biol Endocrinol, 2015, 13: 108.
[10] Saha SA-O, Roy P, Corbitt C, Kakar SS. Application of Stem Cell Therapy for Infertility. LID - 10.3390/cells10071613 [doi] LID - 1613. Cells, 2021, 10(7): 1613.