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Published: 2025-08-21
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DOI: https://doi.org/10.52163/yhc.v66iCD8.3019
Issue
Vol. 66 No. CĐ8-NCKH
Section
Articles
How to Cite
Thủy, H. T. T., & Ngọc, B. T. (2025). 58. AMPLIFICATION OF RESISTANCE TO NEW TB DRUG “BEDAQUILINE” IN TUBERCULOSIS PATIENT AFTER COMPLETION OF TREATMENT. Vietnam Journal of Community Medicine, 66(CĐ8-NCKH). https://doi.org/10.52163/yhc.v66iCD8.3019

58. AMPLIFICATION OF RESISTANCE TO NEW TB DRUG “BEDAQUILINE” IN TUBERCULOSIS PATIENT AFTER COMPLETION OF TREATMENT.

Hoang Thi Thanh Thuy1, Bui Thi Ngoc2
1 National Lung Hospital
2 Hai Duong Lung Hospital

Main Article Content

Abstract

Objective: We report a case of stepwise amplification of drug resistance to the new drug - Bedaquiline in a tuberculosis (TB) patient previously assessed as having completed treatment, with the hope of sharing information to improve the quality of treatment monitoring.


Case report: A 58-year-old male patient with a history of two previous TB treatments was assessed as “complete”. Initially a case of drug-sensitive TB, the patient was found to have developed stepwise resistance to Rifampicin, Fluoroquinolones and especially the new drug “Bedaquiline”.


Discussion: Although there was no evidence of bacterial genome sequencing to exclude the possibility of infection with new strains, or heteroresistance; this case still points towards the possibility of acquired drug resistance due to no history of contact with a drug-resistant TB patient or use of second-line drugs idientified; meanwhile, the patient lacked compliance and re-examination in the final stage of treatment to have sufficient evidence for  accurate treatment outcome assessment.


Conclusion: Vietnam needs solutions to improve the quality of treatment monitoring, re-examination during treatment, and monitoring TB patients after completing treatment to promptly detect and treat cases of relapse with drug resistance amplification.


Keywords: Drug-resistant tuberculosis, Bedaquiline resistance, drug susceptibility testing, treatment monitoring, treatment completion

Article Details

Keywords

Drug-resistant tuberculosis, Bedaquiline resistance, drug susceptibility testing, treatment monitoring, treatment completion

References

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