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Published: 2025-07-10
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DOI: https://doi.org/10.52163/yhc.v66ienglish.2751
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Tập 66 VoL.English Version
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Articles
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Thanh, B. D., & Viet, T. Q. (2025). 15. CLINICAL CHARACTERISTICS, PARACLINICAL FINDINGS, AND TREATMENT OUTCOMES OF PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN THE INTENSIVE CARE UNIT OF MILITARY HOSPITAL 175. Vietnam Journal of Community Medicine, 66(english). https://doi.org/10.52163/yhc.v66ienglish.2751

15. CLINICAL CHARACTERISTICS, PARACLINICAL FINDINGS, AND TREATMENT OUTCOMES OF PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN THE INTENSIVE CARE UNIT OF MILITARY HOSPITAL 175

Bui Duc Thanh1, Tran Quoc Viet1
1 Military Hospital 175

Main Article Content

Abstract

Objective: To describe the clinical and paraclinical characteristics and evaluate treatment outcomes of patients with ventilator-associated pneumonia (VAP).


Subjects and Methods: This is a cross-sectional descriptive study conducted on 76 patients diagnosed with ventilator-associated pneumonia, treated in the Intensive Care Unit at Military Hospital 175 from November 2023 to December 2024.


Results: Among the 76 patients studied, late-onset VAP (≥5 days) accounted for a higher proportion (63.2%) compared to early-onset VAP (<5 days) (36.8%). The majority were male (65.8%) with a mean age of 62.3 ± 14.1 years. Common comorbidities included diabetes mellitus (18.4%) and chronic obstructive pulmonary disease (COPD) (11.8%). Most patients had cerebral hemorrhage (59.2%) and required intubation due to coma (60.5%). Clinical signs included fever (72.4%), leukocytosis (76.3%), hypoxemia (PaO₂/FiO₂ <200 in 51.3%), with a mean Glasgow Coma Scale score of 9.1 ± 2.5 and SOFA score of 5.1 ± 2.4. Gram-negative bacteria were predominant, with Klebsiella pneumoniae (22.4%), Pseudomonas aeruginosa (19.7%), and Acinetobacter baumannii (18.4%) being the most frequently isolated pathogens. The average duration of mechanical ventilation was 8.2 ± 2.6 days, and ICU stay was 10.5 ± 3.1 days. The clinical stabilization rate was 63.2%. Late-onset VAP was significantly associated with age ≥65 years (p=0.012), leukocytosis (p=0.048), elevated procalcitonin (p=0.004), hypoxemia (p=0.001), and multidrug-resistant (MDR) bacteria (p=0.003).


Conclusion: Late-onset VAP accounted for the majority of cases (63.2%), predominantly affecting elderly patients and associated with MDR Gram-negative bacteria. Risk factors such as hypoxemia and elevated procalcitonin were significantly related. The findings highlight the critical need for stringent infection control measures in patients requiring prolonged mechanical ventilation.

Article Details

Keywords

Ventilator-associated pneumonia, intensive care, chronic obstructive pulmonary disease

References

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