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Published: 2025-05-26
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DOI: https://doi.org/10.52163/yhc.v66i3.2539
Issue
Vol. 66 No. 3
Section
Articles
How to Cite
Thảo, T. T. P., Thắm, Đặng T., Trâm, H. T., Linh, T. Điệu, & Đạt, T. T. (2025). 49. THE MOUTHWASH CONTAINING CHLORHEXIDINE AND CHLORINE DIOXIDE: AN IN VITRO STUDY . Vietnam Journal of Community Medicine, 66(3). https://doi.org/10.52163/yhc.v66i3.2539

49. THE MOUTHWASH CONTAINING CHLORHEXIDINE AND CHLORINE DIOXIDE: AN IN VITRO STUDY

Tran Thi Phuong Thao1, Dang Thi Tham1, Huynh To Tram1, Tran Dieu Linh1, Tran Thanh Dat1
1 Faculty of Odonto-Stomatology, Hong Bang Interntaional University

Main Article Content

Abstract

Objective: To evaluate the effect of the mouthwash containing chlorhexidine and chlorine dioxide on human gingival fibroblasts.


Subject and method: The impact of mouthwash containing both chlorhexidine (concentrations from 0.01, 0.02, 0.05, 0.1, and 0.2%) and chlorine dioxide (0.05 and 0.1%) on human gingival fibroblasts after 24 hours of contact was assessed using the colorimetric assay MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide], in accordance with ISO10993-5:2009.


Results: After 24 hours of contact, the mouthwash containing chlorhexidine and chlorine dioxide showed toxicity grades 3 and 4 to the human gingival fibroblast.


Conclusion: The mouthwash containing chlorhexidine and chlorine dioxide was toxic to human gingival fibroblasts after 24 hours of exposure.

Article Details

Keywords

chlorhexidine, chlorine dioxide, human gingival fibroblast, mouthwash.

References

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