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Published: 2025-05-26
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DOI: https://doi.org/10.52163/yhc.v66i3.2520
Issue
Vol. 66 No. 3
Section
Articles
How to Cite
Linh, N. T. D., Nhạn , L. T. T., Huy, T. Đức Q., & Phương, P. T. (2025). 30. RESEARCH ON THE EFFECT OF DRY EXTRACT “THANG THANH GIANG TROC” ON SOME BLOOD INDICATORS OF RATS IN THE MODEL OF CHRONIC KIDNEY DISEASE WITH 5/6 RAT NEPHROLYSIS. Vietnam Journal of Community Medicine, 66(3). https://doi.org/10.52163/yhc.v66i3.2520

30. RESEARCH ON THE EFFECT OF DRY EXTRACT “THANG THANH GIANG TROC” ON SOME BLOOD INDICATORS OF RATS IN THE MODEL OF CHRONIC KIDNEY DISEASE WITH 5/6 RAT NEPHROLYSIS

Nguyen Thi Dieu Linh1, Le Thi Thanh Nhan2, Tran Duc Quang Huy1, Pham Thuy Phuong1
1 Vietnam Academy of Traditional Medicine and Pharmacy
2 Hanoi University of Business and Technology

Main Article Content

Abstract

Objective: Research on the effect of dry extract “Thang thanh giang troc” on some blood indicators of rats in the model of chronic kidney disease with 5/6 rat nephrolysis.


Subject and method: Evaluation of the effect of dry extract of “Thang thanh giang troc” on some blood indices of male Wistar white rat.


Subjects: White Wistar rats, male, adult, healthy, weight from 200 - 250g. Experimental rats were provided by the Animal Department - Military Medical Academy.


Method: Research the effect of dry extract "Thang thanh giang troc" on the model of chronic kidney disease with 5/6 kidney resection in rats.


Results: After 60 days of taking the dried extract “Thang Thanh Giang Troc”


Compared with the model batch, the serum urea concentration of mice in the drug-treated groups decreased significantly with p < 0.01. The serum urea concentration of mice in the Thang thanh giang troc 2 (TTGT-2) group decreased the most, and was statistically significantly different from that in the Thang thanh giang troc 1 (TTGT-1) group (p < 0.05). Compared with the model batch, the serum creatinine concentration of mice in the drug-treated groups decreased significantly with p < 0.01. The serum creatinine concentration of mice in the TTGT-2 group decreased the most, and was statistically significantly different from that in the TTGT-1 group (p < 0.05). Compared with the model batch, the number of red blood cells in mice and the hemoglobin content of mice in the drug-treated groups increased, and was statistically significantly different from that in the TTGT-1 group (p < 0.05). The difference in hematocrit of mouse blood between different batches was not statistically significant (p > 0.05).


Conclusion: The dry extract of "Thang Thanh Giang Troc" at various doses has shown the effect of reducing serum urea and creatinine concentrations, increasing hematological indices of mice in a mouse model of chronic kidney disease.

Article Details

Keywords

“Thang thanh giang troc”, blood index, chronic kidney disease, Wistar white rats.

References

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