12. HEMATOLOGICAL VALUES IN UMBILICAL CORD IN NEWBORNS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Main Article Content
Abstract
Objectives: To describe the characteristics of umbilical cord blood cells and to explore some factors associated with the characteristics of umbilical cord blood cells in newborns.
Subjects and methods: This cross-sectional descriptive study included 58 newborns delivered at the Department of Obstetrics and Gynecology and the Neonatal Care Unit, Hue University of Medicine and Pharmacy Hospital, from March 2024 to December 2024.
Results: The male to female ratio was 1.32 to 1. Term neonates accounted for 51.7%. A low birth weight infants comprised 37.9%. The characteristics of umbilical cord blood cells in newborns were as follows: the median white blood cell count was 12.32 G/l (interquartile range: 9.44-15.18 G/l); the neutrophil count was 5.43 G/l (interquartile range: 39.44-55.01 G/l); the red blood cell count was 4.29 T/l (interquartile range: 4.07-4.49 T/l); the hemoglobin concentration was 154.00 g/l (interquartile range: 142.50-161.00 g/l); and the platelet count was 231.20 G/l (interquartile range: 172.80-281.30 G/l). Preterm newborns had significantly lower white blood cell and neutrophil counts in umbilical cord blood compared to term newborns (p < 0.05). Newborns weighing less than 2500 grams had significantly lower white blood cell and neutrophil counts compared to newborns weighing 2500 grams or more (p < 0.05). Neonates with sepsis had significantly lower white blood cell and neutrophil counts in umbilical cord blood compared to healthy neonates (p < 0.05). Newborns of mothers with anemia had significantly lower umbilical cord blood hematocrit compared to infants of healthy mothers (p < 0.05).
Conclusion: Gestational age, birth weight, nutritional status, and maternal and fetal factors influence umbilical cord blood indices in newborns.
Article Details
Keywords
Newborn, umbilical cord blood cells
References
[2] Huỳnh Thị Minh Lý, Nghiên cứu đặc điểm lâm sàng và tế bào máu cuống rốn ở trẻ sơ sinh non tháng, Luận văn thạc sĩ y học, Trường Đại học Y Dược, Đại học Huế, 2023.
[3] National Committee for Clinical Laboratory Standards, How to Define and Determine Reference Intervals in the Clinical Laboratory; Approved Guideline-Second Edition, NCCLS document C28-A2 [ISBN 1- 56238-406-6], NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898, USA, 2000.
[4] National institute for health and care excellence, Neonatal infection: antibiotics for prevention and treatment, 2021.
[5] American Academy of Pediatrics, Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, 2022.
[6] Rolim A.C.B et al, Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns, Rev Paul Pediatr, 2019, 37 (3), pp. 264-274.
[7] Walka M.M et al, Complete blood counts from umbilical cords of healthy term newborns by two automated cytometers, Acta haematologica, 1999, 100 (4), pp. 167-173.
[8] Bolat A et al, Blood parameters changes in cord blood of newborns of hypertensive mothers, Eur J Pediatr, 2013, 172 (11), pp. 1501-9.
[9] Mougiou V et al, Gestational Diabetes Melitus and Cord Blood Platelet Function Studied via the PFA-100 System, Diagnostics (Basel), 2022, 12 (7).
[10] Agrawal R, Srivastava P, Cord blood hemoglobin levels in relation to maternal anemia, 2018.
[11] Trần Thị Thùy Hương, Nghiên cứu tương quan của chỉ số huyết học và nồng độ CRP của máu cuống rốn với máu ngoại vi trong nhiễm khuẩn sơ sinh sớm ở trẻ sơ sinh non tháng, Luận văn thạc sĩ y học, Trường Đại học Y Dược, Đại học Huế, 2020.
[12] Saboohi E et al, Immature to total neutrophil ratio as an early indicator of early neonatal sepsis, Pak J Med Sci, 2019, 35 (1), pp. 241-246.