6. PREVALENCE, SPECIES COMPOSITION AND AZOLE RESISTANCE OF CANDIDA SPP. IN WOMEN VISITING CAN THO CENTRAL GENERAL HOSPITAL
Main Article Content
Abstract
Background: Vaginitis is a common condition in women, and Candida spp. is one of the frequent causes. Currently, the diagnosis and treatment of Candida spp. In Can Tho city and the Mekong Delta still face some difficulties, along with the increasing resistance of Candida spp.
Objective: Determine the prevalence, species composition, and azole resistance rate of Candida spp. isolated from women visiting Can Tho Central General Hospital.
Subject and method: A cross-sectional descriptive study on 160 samples of vaginal discharge from women visiting the Obstetrics and Gynecology clinic at Can Tho Central General Hospital. The vaginal discharge samples were cultured, identified and performed to antifungal susceptibility testing.
Result: The prevalence of vaginal Candidiasis in women visiting the clinic was 35.6%, in which Candida albicans is the most prevalent species (66.7%). The isolated Candida spp. showed resistance to fluconazole, itraconazole, ketoconazole, and voriconazole, with resistance proportion of 21.1%, 45.6%, 10.5%, and 14.0%, respectively.
Conclusion: The prevalence of vaginal Candidiasis in women remains high, and Candida albicans is the primary pathogen. Additionally, these species exhibit a high rate of resistance to fluconazole and itraconazole.
Article Details
Keywords
Candida, vaginitis, culture, identification, resistance
References
[2]. Fakhim H, Vaezi A, Javidnia J. (2020), Candida africana vulvovaginitis: Prevalence and geographical distribution. J Mycol Med. Vol.30(3):100966. doi:10.1016/j.mycmed.100966
[3]. Nsenga L, Bongomin F. et al (2022), Recurrent Candida Vulvovaginitis.Venereology. Vol.1(1): pp.114-123. doi: https://doi.org/10.3390/venereology1010008
[4]. Nguyễn TH, Vũ HL, Lê HD, Ninh TD, Trần CV. Tỷ lệ và định danh chủng nấm Candida gây viêm âm đạo bằng môi trường Brilliance Candida Agar và kỹ thuật khối phổ Maldi - Tof. Tạp chí Da liễu học Việt Nam. 2023;(41):39-47. doi: https://doi.org/10.56320/tcdlhvn.41.115
[5]. Nguyễn MH, Phạm BTT, Nguyễn HNT. Tình hình nhiễm nấm tại Bệnh viện Nguyễn Tri Phương giai đoạn 2020 - 2022. Tạp chí Y học Việt Nam. 2024;534(1B): 138 - 142. doi: 10.51298/vmj.v534i1B.8261
[6]. Trang THN. Một số đặc điểm cận lâm sàng giúp định danh tác nhân viêm âm đạo. Tạp chí Y học Việt Nam. 2022;513(1): 227 - 231. doi: https://doi.org/10.51298/vmj.v513i1.2372
[7]. Sustr V, Foessleitner P, Kiss H, Farr A. Vulvovaginal Candidosis: Current Concepts, Challenges and Perspectives. J Fungi (Basel). 2020;6(4). doi:10.3390/jof6040267
[8]. Sobel JD. Treatment of vaginitis caused by non-albicans Candida species. Expert Rev Anti Infect Ther. 2024;22(5):289-296. doi:10.1080/14787210.2024.2347953
[9]. Pristov KE, Ghannoum MA. Resistance of Candida to azoles and echinocandins worldwide. Clin Microbiol Infect. 2019;25(7):792-798. doi:10.1016/j.cmi.2019.03.028
[10]. Maraki S, Mavromanolaki VE, Stafylaki D, Nioti E, Hamilos G, Kasimati A. Epidemiology and antifungal susceptibility patterns of Candida isolates from Greek women with vulvovaginal candidiasis. Mycoses. 2019;62(8):692-697. doi:10.1111/myc.12946