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Published: 2025-03-04
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DOI: https://doi.org/10.52163/yhc.v66i2.2036
Issue
Vol. 66 No. 2
Section
Articles
How to Cite
Hùng, Đặng N., Huy, N. Đỗ, Cường, T. Q., Huyền, L. T. T., Tươi, V. T., Hằng, Đinh T. T., Nguyệt, T. T. M., & Ngọc, N. N. (2025). 2. INTERVENTION TO IMPROVE BONE DENSITY USING VITAMIN K2 SUPPLEMENTS IN POSTMENOPAUSAL WOMEN AGED 45 AND ABOVE IN LAM DONG PROVINCE IN 2023-2024. Vietnam Journal of Community Medicine, 66(2). https://doi.org/10.52163/yhc.v66i2.2036

2. INTERVENTION TO IMPROVE BONE DENSITY USING VITAMIN K2 SUPPLEMENTS IN POSTMENOPAUSAL WOMEN AGED 45 AND ABOVE IN LAM DONG PROVINCE IN 2023-2024

Dang Ngoc Hung1, Nguyen Do Huy2, Tran Quoc Cuong3, Le Thi Thu Huyen4, q1, Dinh Thi Thu Hang5, Tran Thi Minh Nguyet5, Nguyen Nguyen Ngoc6
1 Nutrition Research and Consulting Institute NRECI
2 Vietnam National University, Hanoi
3 Pham Ngoc Thach University of Medicine
4 Institute of Community Medicine Research and Training MRIT
5 National Institute of Nutrition
6 Save the Children International in Vietnam

Main Article Content

Abstract

Objectives: To evaluate the effectiveness of improving bone density through supplementation in postmenopausal women aged 45 and above in Lam Dong province in 2023-2024.


Objects and methods: This community intervention study, monitored over 6 months was conducted among postmenopausal women aged 45 and above with osteopenia. The intervention group I received supplements of vitamin K2, calcium, and vitamin D3, while intervention group II received calcium and vitamin D3 supplements.


Results: In intervention group I, the average Osteocalcin index decreased from 21.08 ± 10.39 ng/mL to 18.28 ± 8.08 ng/mL (p < 0.001); similarly, intervention group II also recorded a decrease in Osteocalcin index from 21.42 ± 6.83 ng/mL to 19.29 ± 6.77 ng/mL (p = 0.003). For β-CTX index, intervention group I decreased from 351.27 ± 177.05 ng/mL to 236.78 ± 129.19 ng/mL (p < 0.001); meanwhile, intervention group II decreased from 298.58 ± 141.82 ng/mL to 284.61 ± 170.90 ng/mL, but the difference was not statistically significant (p = 0.568).


Conclusions: Supplementing vitamin K2 combined with calcium and vitamin D3 significantly changed bone turnover markers compared to the group supplementing only calcium and vitamin D3.

Article Details

Keywords

Bone density reduction, nutritional products, vitamin K2, postmenopausal women, Lam Dong

References

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