21. EVALUATION OF ANTITUSSIVE AND EXPECTORANT EFFECTS OF BAO PHE LINH LIQUID EXTRACT ON SWISS ALBINO MICE
Main Article Content
Abstract
Aims: The study aims to evaluate the antitussive and expectorant effects of Bao Phe Linh liquid extract in Swiss albino mice.
Subjects and methods: An experimental study was conducted on 80 Swiss albino mice, divided into four groups (control, reference, and two doses of Bao phe linh). Antitussive effects were assessed using an ammonia-induced cough model, while expectorant effects were evaluated by quantifying phenol red secretion from the trachea. Data were statistically analyzed using the t-test and presented as ± SD with a significance level of p < 0.05.
Results: Bao phe linh significantly prolonged the latency to the first cough and reduced the number of coughs in 5 minutes, with inhibition rates of 24.37% and 30.82% for the low and high doses, respectively. The phenol red secretion increased to 0.353 µg/ml (low dose) and 0.382 µg/ml (high dose) compared to 0.260 µg/ml in the control group (p < 0.01), showing comparable efficacy to N-acetylcysteine (0.404 µg/ml).
Conclusions: Bao phe linh liquid extract exhibits significant antitussive and expectorant effects. Further studies are needed to evaluate its efficacy and safety in clinical settings.
Article Details
Keywords
Bao phe linh, antitussive, expectorant, upper respiratory tract infections, animal experiment
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