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Published: 2025-01-24
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DOI: https://doi.org/10.52163/yhc.v66iCD1.1962
Issue
Vol. 66 No. CD1 (2025)
Section
Articles
How to Cite
Bạch, N. V., Trà My, B. T. ., Trung, T. N., Toàn, N. T. ., Vân, N. T. H., & Ánh, C. V. (2025). 2. VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF MELOXICAM IN ANTI-INFLAMMATORY FILM. Vietnam Journal of Community Medicine, 66(CD1). https://doi.org/10.52163/yhc.v66iCD1.1962

2. VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF MELOXICAM IN ANTI-INFLAMMATORY FILM

Nguyen Van Bach1, Bui Thi Tra My1, Trinh Nam Trung1, Nguyen Truong Toan1, Nguyen Thi Hong Van1, Cao Van Anh1
1 Vietnam Military Medical University

Main Article Content

Abstract

Objective: To validate a method for the quantification of Meloxicam in film by high performance liquid chromatography in order to contribute to product quality standardization.


Subjects and methods: Quantitative Meloxicam by high performance liquid chromatography method with GRACE Apollo C18 (4.6 × 250 mm, 5 µm), flow rate 1.0 ml/min, detector UV at 354 nm, injection volume 10 µl, mobile phase consisting of acetonitril, distilled water and glacial acetic acid (55:40:5).


Results: The method ensured suitability, specificity, linearity, repeatability, and precision as specified by ICH.


Conclusions: The quantitative method meets the requirements and can be used for the quantification of Meloxicam in film.

Article Details

Keywords

Meloxicam, HPLC, fast dissolving films

References

[1] Bộ Y tế, Dược thư quốc gia Việt Nam, tập 2, 2022, tr. 1074-1075.
[2] Türck D, Busch U, Heinzel G et al, Clinical pharmacokinetics of Meloxicam, Arzneimittelforschung, 1997, 47 (3), 253-258.
[3] Peter L, Klaus D, Wolfhard E et al, Structure and physicochemical properties of Meloxicam, a new NSAID, 1996, Eur. J. Pharm. Sci, 4 (3), 175-187.
[4] Aggarwal J, Singh G, Saini S et al, Fast dissolving films: A novel approach to oral drug, Internaltional research journal of pharmacy, 2011, 2 (12), 69-74.
[5] Shrimali C, Patel G, Bhimani B, Formulation and evaluation of fast dissolving oral film of Meloxicam, Internationl journal of pharmaceutical research and bio-science, 2005, 4(2), 378-387.
[6] Ankita C, Pranati S, Sunita Y et al, Fast dissolving films: A review, Current Drug Delivery, 2011, 8(4), pp. 373-380.
[7] Francine R, Luciane V, Alexandre M et al, Validation of high performance liquid chromatography method for determination of Meloxicam loaded PEGylated nanocapsules, Braz. J. Pharm. Sci, 2015, 51 (4), 823-832.
[8] Nalini K, Madhusmita S, Podilapu S et al, Validation of assay indicating method development of Meloxicam in bulk and some of its tablet dosage forms by RP-HPLC, Springerplus, 2014, 3(95), 1-6.
[9] ICH, Validation of analytical procedures: text and methodology, 2022, Q2(R2).