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Published: 2025-01-07
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DOI: https://doi.org/10.52163/yhc.v66i1.1955
Issue
Vol. 66 No. 1
Section
Articles
How to Cite
Huệ, P. T. K., Thảo, Đỗ T., Ngân, T. T. Q., Ngọc, N. L. B., Đường, N. T., Sỹ, L. D., Minh, L. N., Công, H., & Viễn, L. T. (2025). 50. EVALUATION OF ACUTE TOXICITY OF SCORPION TURMERIC (CURCUMA RANGJUED)’S RHIZOME EXTRACTS FOR POTENTIAL MEDICINAL USE ON HUMANS. Vietnam Journal of Community Medicine, 66(1). https://doi.org/10.52163/yhc.v66i1.1955

50. EVALUATION OF ACUTE TOXICITY OF SCORPION TURMERIC (CURCUMA RANGJUED)’S RHIZOME EXTRACTS FOR POTENTIAL MEDICINAL USE ON HUMANS

Phung Thi Kim Hue1,2, Do Thi Thao1,3, Tran Thi Quynh Ngan2, Nguyen Le Bao Ngoc2, Nguyen Thi Duong4, Le Dung Sy1, Le Nhat Minh5, Ho Cong4, Le Tri Vien1
1 Institute of Health Research and Educational Development in Central Highlands
2 Hung Vuong High School for the Gifted
3 Institute of Biotechnology, Vietnam Academy of Science and Technology
4 Thao Nguyen Duong Family Heirloom Traditional Medicine Clinic
5 Foreign Trade University

Main Article Content

Abstract

Objective: To evaluate the acute toxicity of rhizome extracts of Curcuma rangjued on mouse model.


Methodology: The acute toxicity testing was conducted in accordance with the OECD guideline 420 and the Vietnamese Ministry of Health's guidelines for preclinical and clinical trials of traditional and herbal medicines (Decision No. 141/QĐ-K2ĐT, released on 27 October, 2015).


Results: Oral administration of Curcuma rangjued’s rhizome extracts at the dose of 5000 mg/kg did not induce acute toxicity in mice.


Conclusions: Curcuma rangjued is a promising medicinal resource, proven to be safe and non-toxic at doses up to 5000 mg/kg body weight in experimental mice. Therefore, expanding the cultivation of Curcuma rangjued to harness this valuable medicinal resource could significantly contribute to public health.

Article Details

Keywords

Curcuma rangjued, acute toxicity, mouse model, oral administration

References

[1] Phung Thi Kim Hue et al, Taxonomic identification of an additional species, Curcuma rangjued, in the Central Highlands of Vietnam and evaluation of its inhibitory activities against cancer cell lines, Vietnam Journal of Community Medicine, Vol. 65, English version, 2024, pp. 25-30.
[2] Phung Thi Kim Hue et al, Effects of glycemic regulation and acetylcholinesterase inhibition of scorpion turmeric (Curcuma rangjued) in Central Highlands, Vietnam, Vietnam Journal of Community Medicine, Vol. 65, English version, 2024, pp. 41-46.
[3] Bộ Y tế, Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu, Quyết định số 141/QĐ-K2ĐT ngày 27 tháng 10 năm 2015.
[4] Organization for Economic Cooperation and Development (OECD), OECD guidelinesfor testing of chemicals, Section 4, health effects: Test No. 425: Acute oral toxicity: Up-and-down procedure, 2008.
[5] OECD guidelinesfor testing of chemicals, Section 4, health effects: Test No. 420: Acute oral toxicity, Fixed Dose Procedure, 2001.
[6] Akhila J.S, Deepa S, Alwar M.C, Acute toxicity studies and determination of median lethal dose, Curr Sci, 2007, 93: 917-920.
[7] TrM4re A, Sylvin OuedrM4go, Adama Kabore, Hamidou H Tamboura and I Pierre Guissou, The acute toxicity in mice and the in vitro anthelminthic effects on Haemonchus contortus of the extracts from three plants (Cassia ieberiana, Guiera senegalensis and Sapium grahamii) used in traditional medicine in Burkina Faso, Annals of Biological Research, 2014,5 (2): 41-46.
[8] Panda S.K, Tiwari P, Adhikari L, Acute Oral Toxicity Study of Turmeric Based Herbal Product in Sprague Dawley Rats, International journal of health sciences, 2022, 6 (S6), 1701-1706.
[9] Walum E, Acute oral toxicity, Environmental health perspectives, 1998, 106 (suppl 2): 497-503.