29. NVESTIGATION OF ACUTE AND SUB-CHRONIC ORAL TOXICITY STUDIES OF STANDARDIZED EXTRACT FROM LAI CHAU GINSENG (PANAX VIETNAMENSIS VAR. FUSCIDISCUS K. KOMATSU, S. ZHU & S.Q. CAI) CULTIVATED IN SIN HO
Main Article Content
Abstract
Objective: To investigate the acute and sub-chronic toxicity of standardized extracts from Lai Chau ginseng cultivated in Sin Ho District, Lai Chau Province.
Subjects and methods: The standardized extract of Lai Chau ginseng was prepared at the Traditional Medicine Hospital of Ho Chi Minh City from 5-year-old Lai Chau ginseng (Panax vietnamensis var. fuscidiscus K.Komatsu, S.Zhu & S.Q.Cai) grown at an altitude above 2,000 meters in Sin Ho district, Lai Chau province. Acute and sub-chronic toxicity studies were conducted on Swiss albino mice.
Results: The Lai Chau ginseng extract showed no acute toxicity, with a maximum tolerated dose (Dmax) of 49.39 g/kg. The extract did not affect general physical condition or induce changes in hematological, biochemical parameters, or histological structure of the heart, liver, and kidneys in the mice administered doses of 75, 150, and 300 mg/kg over a period of 60 days.
Conclusion: Lai Chau ginseng extract was found to be non-toxic in mice.
Article Details
Keywords
Lai Chau ginseng cultivated, Panax vietnamensis var. fuscidiscus K. Komatsu, S. Zhu & S.Q. Cai, acute toxicity, semi-chronic toxicity
References
[2] Đỗ Thị Hà , Vũ Thị Diệp , Lê Thị Loan , et al. Một số kết quả bước đầu nghiên cứu thành phần hoá học, xây dựng tiêu chuẩn cơ sở và dấu vân tay hoá học Sâm Lai Châu (Panax vietnamensis var. fuscidiscus). Báo cáo Hội thảo “Bảo tồn và phát triển sâm Lai Châu tại huyện Mường Tè”. Viện Dược liệu và Viện Nghiên cứu Lâm sinh. 2016;
[3] Kim CY, Kim YG, Sin SJ, Koo H, Cheon K, Kim D. Preventive effect of mebicar and ginsenoside Rg1 on neurobehavioral and immunological188 www.tapchiyhcd.vn disruptions caused by intermittent unpredictable stress in mice. Neuroimmunomodulation. 2018;25(1):49-58. doi:10.1159/000489634
[4] Wu JJ, Yang Y, Wan Y, et al. New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Aug 2022;152:113207. doi:10.1016/j.biopha.2022.113207
[5] Ni XC, Wang HF, Cai YY, et al. Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke. Redox biology. Aug 2022;54:102363. doi:10.1016/j.redox.2022.102363
[6] Jeong J-J, Van Le TH, Lee S-Y, et al. Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages. International Immunopharmacology. 2015;28(1):700-706.
[7] Jeong JJ, Van Le TH, Lee SY, et al. Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages. International immunopharmacology. Sep 2015;28(1):700-706. doi:10.1016/j.intimp.2015.07.025
[8] Đỗ Trung Đàm. Phương pháp xác định độc tính cấp của thuốc. Nhà xuất bản Y học; 2014:15 -157; 199 - 215.