21. A CASE OF HYPOGONADISM IN A YOUNG HIV-POSITIVE PATIENT AND A REVIEW OF LITERATURE

Nguyen Truong Manh1, Le Thanh Sang2, Nguyen Nhat Minh3
1 Hanh Phuc International Hospital
2 Hanh Phuc International Hospita
3 Hue University of Medicine and Pharmacy

Main Article Content

Abstract

 Introduction: Hypogonadism is a common abnormality in HIV-infected men (Human Immunodeficiency Virus) and can have implication for sexual function and body metabolism. However, this condition often remains silent, underdiagnosed, and inadequately treated.


Case Report: We report a case of a 28-year-old male patient diagnosed with HIV infection 5 years ago, continuously treated with antiretroviral drugs (ARVs) with a good response. The patient presented with symptoms of decreased libido, erectile dysfunction, and difficulty ejaculating in the past 2 years. Clinical examination revealed a slightly feminine physique, with both testes showing mild reduction in size. Laboratory tests indicated severely decreased levels of testosterone, FSH, and LH. The patient was treated with transdermal testosterone daily and Tadalafil on-demand. After 3 months of treatment, there was a significant improvement in symptoms, clinical manifestations, and endocrine parameters.


Conclusion: Early screening for hypogonadism in HIV-infected male individuals and the use of testosterone therapy can improve the quality of life for these patients.

Article Details

References

[1] The Joint United Nations Programme on HIV and
AIDS. Global HIV & AIDS statistics. Available
from: https://www.unaids.org/en/resources/factsheet.
[2] Antiretroviral Therapy Cohort Collaboration.
Survival of HIV-positive patients starting
antiretroviral therapy between 1996 and 2013:
a collaborative analysis of cohort studies.
Lancet HIV. 2017;4(8):e349–e356. https://doi.
org/10.1016/S2352-3018(17)30066-8.
[3] Guaraldi G, Rockwood K, GeriatricHIV Medicine
Is Born. Clin Infect Dis. 2017;65(3):507–509.
https://doi.org/10.1093/cid/cix316.
[4] Santi D, Spaggiari G, Vena W et al., The
Prevalence of Hypogonadism and the
Effectiveness of Androgen Administration on
Body Composition in HIV-Infected Men: A
Meta-Analysis. Cells. 2021;10(8):2067. https://
doi.org/10.3390/cells10082067.
[5] Wong N, Levy M, Stephenson I, Hypogonadism
in the HIV-Infected Man. Curr Treat Options
Infect Dis. 2017;9(1):104–116. https://doi.
org/10.1007/s40506-017-0110-3.
[6] Iddi S, Dika H, Kidenya B et al., Prevalence
of Hypogonadism and Associated Risk Factors
among Newly Diagnosed ART Naïve HIVInfected
Males in Mwanza, Tanzania. Int J
Endocrinol. 2024;2024:9679935. https://doi.
org/10.1155/2024/9679935.