2. SHORT-TERM OUTCOMES OF RIGHT HEPATECTOMY FOR INTRAHEPATIC CHOLANGIOCARCINOMA IN THE DEPARTMENT OF HEPATOLOGY, VIETNAM NATIONAL CANCER HOSPITAL FROM 2017 TO 2022

Pham Ba Duc1, Pham The Anh1, Nghiem Thanh Ha1
1 National Cancer Hospital

Main Article Content

Abstract

Objective: To evaluate the short-term outcomes of right hepatectomy for intrahepatic cholangiocarcinoma.


Subject and method: This was a retrospective descriptive study of the cases who underwent right hepatetomy for intrahepatic cholangiocarcinoma at Department of hepatobiliary and pancreatic surgery in National cancer hospital from March 2017 to November 2022.


Result: Elective surgery was performed for 27 patients. The average age was 60.2 ± 11.2 years, sex ratio was 1.25 male per 1 female; 18.5% of cases had a history of hepatolithiasis; hepatitis B and hepatitis C related: 68.3%. Elevated of CA 19-9 and CEA levels were seen in 77.8% and 55.6% of cases respectively. Anatomical right hepatectomy has the majority (81.5%); regional lymphadenectomy was performed in 11.1% of cases. Most of patients had the solitary tumor (51.8%) with its size being larger than 5cm (63%). Postoperative pathology: cholangiocarcinoma (81.5%), lymph node metastases (11.1%), IIIA TNM staging (66.7%). The mean operation time was 166.3 ± 55.4 min. Postoperative complications have the majority in pleural effusion (22.2%) and liver failure (14.8%). The classification of complications according to Clavien – Dindo were: I (66.7%), II (18.5%), IIIa (14.8%).


Conclusion: Right hepatectomy for intrahepatic cholangiocarcinoma is a feasible, safe and effective method.

Article Details

References

[1] Banales JM, Marin JJ, Lamarca A et al.,
Cholangiocarcinoma 2020: the next horizon in
mechanisms and management, Nature reviews
Gastroenterology & hepatology, 17 (9), 2020,
pp. 557-588.
[2] Trần Quốc Đạt, Nghiên cứu đặc điểm lâm sàng,
cận lâm sàng và kết quả phẫu thuật cắt gan do
ung thư đường mật trong gan, Luận văn bác sĩ
nội trú Đại học Y Hà Nội, 2010.
[3] Shimada M, Yamashita Y, Aishima S et al.,
Value of lymph node dissection during resection
of intrahepatic cholangiocarcinoma, Journal of
British Surgery, 88 (11), 2001, pp. 1463-1466.
[4] Gil E, Joh J-W, Park HC et al., Predictors
and patterns of recurrence after curative liver
resection in intrahepatic cholangiocarcinoma,
for application of postoperative radiotherapy: a
retrospective study, World journal of surgical
oncology, 13, 2015, pp. 1-9.
[5] Nguyễn Thị Duyên, Nguyễn Thúy Hương, Đặc
điểm giải phẫu bệnh của ung thư biểu mô đường
mật trong gan theo phân loại WHO 2019 tại15
Bệnh viện Bạch Mai giai đoạn 2019-2022, Tạp
chí Y học Việt Nam, 521 (2), 2022.
[6] Nishikawa H, Osaki Y, Clinical significance
of occult hepatitis B infection in progression
of liver disease and carcinogenesis, Journal of
Cancer, 4 (6), 2013, pp. 473.
[7] Chen HY, Juan CC, Ker CG., Laparoscopic
liver surgery for patients with hepatocellular
carcinoma, Annals of surgical oncology, 15, pp.
800-806, 2008.
[8] Harrison L, Fong Y, Klimstra D et al., Surgical
treatment of 32 patients with peripheral
intrahepatic cholangiocarcinoma, British journal
of surgery, 85 (8), pp. 1068-1070, 1998.
[9] Lê Lộc, Kinh nghiệm qua 1245 trường hợp cắt
gan ung thư, Tạp chí Gan mật Việt Nam, 13, pp.
36 – 45, 2010.
[10] Văn Tần, Ung thư gan nguyên phát: Chỉ định
điều tri, phẫu thuật và kết quả, Y học TP HCM,
8(1), 2004, pp. 589-600.