Main Article Content
Hypertension is a disease that seriously affects the health and life expectancy of the community, playing a major etiological role in target organ damage. The selection of antihypertensive drugs to ensure reasonable safety and effectiveness is always a matter of concern of the medical industry. Applying the cross-sectional method on 2,640 patients being examined and treated for hypertension at Nam Dinh general hospital, it was found that 54.67% female patients accounted for the majority. The age of disease in both sexes is over 50 years old with a relatively high frequency of comorbidities. Most of them were prescribed drug combinations in treatment 77,9%. The group of ACE inhibitors + calcium blockers is the most common combination. ACE inhibitors are also the most commonly prescribed drugs in monotherapy. 11,4% of cases had adverse drug interactions, the most dangerous combination is UCMC + Potassium chloride and UCMC + Spironolactone causing hypokalemia. The most common interaction between beta-blockers and calcium blockers increases the antihypertensive effect.
Hypertension, target blood pressure, drug for hypertension
 Ministry of Health, Guidelines for the diagnosis and treatment of hypertension, 2010. (in Vietnamese)
 Ngoc L, Nearly 60% of people with undetected hypertension in Vietnam nearly 60 people with undetected hypertension in Vietnam, 2020. (in Vietnamese)
 Huyen HTK, Clinical pharmacology, basic principles and drug use in treatment, Medical Publishing House, 2014. (in Vietnamese)
 Khai PG, Recommendation 2010 of the Vietnam Society of Cardiology on the diagnosis and treatment of hypertension, 2010. (in Vietnamese)
 Trong LN, Chien DK, Drug interactions and notes when ordering drugs, Medicine Publishing House, 2006. (in Vietnamese)