ENDOSCOPIC AND HISTOPATHOLOGICAL CHARACTERISTICS OF GASTRIC LESIONS SUSPECTED OF EARLY GASTRIC CANCER AND PRECANCEROUS LESIONS

Nguyen Van De1, Le Thi Thuy2,3, Tong Duc Minh2, Nguyen Hoang Trung2
1 108 Military Central Hospital
2 Vietnam Military Medical University
3 Military Hospital 4, Military Region 4

Nội dung chính của bài viết

Tóm tắt

Objective: To describe the endoscopic and histopathological characteristics of gastric lesions suspected of early gastric cancer and precancerous lesions.


Methods: A cross-sectional study was conducted on 200 patients with gastric lesions detected on endoscopy at 108 Military Central Hospital from 2020 to 2024. All patients underwent magnifying narrow-band imaging (NBI) endoscopy and chromoendoscopy. Lesions suspected of early gastric cancer according to Japanese endoscopic criteria were biopsied for histopathological diagnosis.


Results: Most lesions had a size ≤ 1 cm (51.0%). NBI endoscopy showed that 51% of lesions had no clear demarcation line; nearly half exhibited a homogeneous microsurface pattern and regular microvascular pattern. Thirty-five lesions suspected of early gastric cancer were biopsied; histopathology revealed early gastric cancer in 42.9%, high-grade dysplasia in 34.2%, low-grade dysplasia in 17.1%, and chronic inflammation in 5.8%. Among the 35 lesions suspected of early gastric cancer on endoscopy, 94.2% were confirmed as early gastric cancer or precancerous lesions on histopathology.


Conclusion: This study shows that early gastric cancer and precancerous gastric lesions present with diverse endoscopic appearances and histopathological patterns.

Chi tiết bài viết

Tài liệu tham khảo

1. Sung Hyuna, Ferlay Jacques, Siegel Rebecca L, et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3): 209-249.
2. Tan Yimei, Liu Shuanghua, Tao Shaohong, et al. (2024). Comparison of different treatment strategies for T3N1-3 stage gastric cancer based on the SEER database. Scientific Reports, 14(1): 11210.
3. Young Edward, Philpott Hamish, Singh Rajvinder (2021). Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold. World Journal of Gastroenterology, 27(31): 5126.
4. Yao K. (2013). The endoscopic diagnosis of early gastric cancer. Ann Gastroenterol, 26(1): 11-22.
5. Japanese Gastric Cancer Association (2021). Japanese gastric cancer treatment guidelines 2018 Japanese Gastric Cancer Association. Gastric cancer, 24(1): 1-21.
6. Yao K., Uedo N., Kamada T., et al. (2020). Guidelines for endoscopic diagnosis of early gastric cancer. Dig Endosc, 32(5): 663-698.
7. Chung II-Kwun, Lee Jun Haeng, Lee Suck-Ho, et al. (2009). Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study. Gastrointestinal endoscopy, 69(7): 1228-1235.
8. Isomoto Hajime, Shikuwa Saburo, Yamaguchi Naoyuki, et al. (2009). Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut, 58(3): 331-336.
9. Yao K, Anagnostopoulos GK, Ragunath K (2009). Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy, 41(05): 462-467.
10. Lee Jonathan WJ, Lim Lee Guan, Yeoh Khay Guan (2017). Advanced endoscopic imaging in gastric neoplasia and preneoplasia. BMJ open gastroenterology, 4(1): e000105.