ASSOCIATION BETWEEN LEAD CONCENTRATIONS IN BLOOD, THYROID TISSUE, AND THYROID CANCER
Nội dung chính của bài viết
Tóm tắt
Background: Current research on lead (Pb) in relation to the thyroid and particularly thyroid cancer remains limited.
Objective: To compare Pb concentrations in blood and thyroid tissue samples between the patient and control groups; evaluate the association between Pb concentrations and thyroid cancer.
Methods: A cross-sectional descriptive study was conducted on 282 patients with benign and malignant thyroid tumors at stages 1, 2, and 4. Lead concentrations in blood and thyroid tissue were measured, and their correlation with thyroid cancer was analyzed.
Results: The blood Pb concentration in the patient group was 1.27 ± 2.33 µg/L, while in the control group, it was 0.65 ± 2.35 µg/L. The Pb concentration in thyroid tissue for the benign and malignant groups was 15.26 ± 72.87 µg/kg and 36.88 ± 74.32 µg/kg, respectively. Logistic regression analysis showed that blood Pb levels in the malignant thyroid tumor group were higher than in the benign group (OR = 1.270; 95% CI: 1.011–1.594; p = 0.040). High Pb concentrations in thyroid tissue were associated with thyroid cancer (OR = 1.006; 95% CI: 1.000–1.011; p = 0.043).
Conclusion: High Pb concentrations in thyroid tissue and blood samples are associated with thyroid cancer.
Chi tiết bài viết
Từ khóa
Blood lead concentration, thyroid tissue lead concentration, thyroid cancer.
Tài liệu tham khảo
[2] Kim NH, Hyun YY, Lee KB (2015) Environmental heavy metal exposure and chronic kidney disease in the general population. J Korean Med Sci 30:272–277.
[3] Chi Zhang1 • Hua-Bing Wu1 • Meng-Xia Cheng. Association of exposure to multiple metals with papillary thyroid cancer risk in China. Environmental Science and Pollution Research (2019) 26:20560–20572
[4] Liu Yihao, Su Lei, Xiao Haipeng (2017). Review of factors related to the thyroid cancer epidemic. International journal of endocrinology, 2017(1): 5308635.
[5] Tessler Franklin N, Middleton William D, Grant Edward G, et al. (2017). ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS committee. Journal of the American college of radiology, 14(5): 587-595.
[6] Schneider David F, Chen Herbert (2013). New developments in the diagnosis and treatment of thyroid cancer. CA: a cancer journal for clinicians, 63(6): 373-394.
[7] Bikas Athanasios, Burman Kenneth D (2019), Epidemiology of thyroid cancer, in The Thyroid and Its Diseases: A Comprehensive Guide for the ClinicianSpringer, 541-547.
[8] Li Hui, Li Xiang, Liu Jie, et al. (2017). Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. International journal of environmental health research, 27(5): 409-419.
[9] López CM, Piñeiro AE, Núñez N, Avagnina AM, Villaamil EC, Roses OE (2000) Thyroid hormone changes in males exposed to lead in the Buenos Aires area (Argentina). Pharmacol Res 42:599–602
[10] Chung Hye-Kyung, Nam Ji Sun, Ahn Chul Woo, et al. (2016). Some elements in thyroid tissue are associated with more advanced stage of thyroid cancer in Korean women. Biological trace element research, 171(1): 54-62.