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Đã xuất bản: 2025-06-26
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DOI: https://doi.org/10.52163/yhc.v66ienglish.2735
Số xuất bản
Tập 66 Số Tiếng Anh
Chuyên mục
Bài báo khoa học
Cách trích dẫn
Duc, N. V., Nhat, V. V., Su, H. X., Ben, N. H., Phuong, N. M., Giang, N. T., Thang, L. V., Van, D. T., Ha, N. T. T., Kham, H. P., & Toan, P. Q. (2025). 3. INVESTIGATION OF BK VIRUS INFECTION CHARACTERISTICS IN PATIENTS WITH END-STAGE CHRONIC KIDNEY DISEASE BEFORE KIDNEY TRANSPLANTATION AT MILITARY HOSPITAL 103. Tạp Chí Y học Cộng đồng, 66(english). https://doi.org/10.52163/yhc.v66ienglish.2735

3. INVESTIGATION OF BK VIRUS INFECTION CHARACTERISTICS IN PATIENTS WITH END-STAGE CHRONIC KIDNEY DISEASE BEFORE KIDNEY TRANSPLANTATION AT MILITARY HOSPITAL 103

Nguyen Van Duc1, Vo Van Nhat2, Hoang Xuan Su2, Nguyen Huu Ben2, Nguyen Minh Phuong2, Ngo Truong Giang2, Le Viet Thang1, Diem Thi Van1, Nguyen Thi Thu Ha1, Hoang Phuc Kham1, Pham Quoc Toan1
1 Military Hospital 103
2 Vietnam Military Medical University

Nội dung chính của bài viết

Tóm tắt

Objectives: Investigate BK (Human polyomavirus) virus infection characteristics and their association with selected clinical and subclinical features in end-stage renal disease patients before kidney transplantation.


Patients and methods: A cross-sectional study, including 80 kidney transplant patients and 80 healthy kidney donors at Military Hospital 103. Venous blood samples were collected and anticoagulated with ethylenediaminetetraacetic acid (EDTA). BK-IgG antibodies were detected using the ELISA kit.


Results and discussions: In a cohort of 80 patients with end-stage chronic kidney disease, 21.3% (17/80) tested seropositive for BK-IgG, while 78.7% (63/80) were seronegative, showing no significant difference compared to the healthy control group. The prevalence of BK virus seropositivity was not significantly associated with age, gender, body mass index (BMI), etiology of renal failure, duration of dialysis, pre-transplant dialysis modality, or anemia status.


 Conclusion: Latent BK virus infection was detected at a significant prevalence using serological methods in end-stage chronic kidney disease patients before kidney transplantation.

Chi tiết bài viết

Từ khóa

Kidney transplantation, BK virus, BK-IgG, clinical, paraclinical.

Tài liệu tham khảo

[1] Schwarz, A., et al., Viral origin, clinical course, and renal outcomes in patients with BK virus infection after living-donor renal transplantation. Transplantation, 2016. 100(4): p. 844-853.
[2] Hirsch, H.H. and J. Steiger, Polyomavirus Bk. The Lancet Infectious Diseases, 2003. 3(10): p. 611-623.
[3] Nickeleit, V., et al., BK-virus nephropathy in renal transplants—tubular necrosis, MHC-class II expression and rejection in a puzzling game. Nephrology Dialysis Transplantation, 2000. 15(3): p. 324-332.
[4] Hirsch, H.H., et al., Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. New England Journal of Medicine, 2002. 347(7): p. 488-496.
[5] Ramos, E., et al., The decade of polyomavirus BK-associated nephropathy: state of affairs. Transplantation, 2009. 87(5): p. 621-630.