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Published: 2026-04-21
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Issue
Vol. 67 No. CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026
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Articles
How to Cite
Châu, L. T. M., Tính, T. T. T., Đức, N. T., & Tuấn, L. Q. (2026). CREATININE-TO-CYSTATIN C RATIO AND DISCORDANCE IN RENAL FUNCTION ASSESSMENT AMONG OUTPATIENTS WITH TYPE 2 DIABETES MELLITUS DURING ACUTE HYPERGLYCEMIA. Vietnam Journal of Community Medicine, 67(CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026). Retrieved from http://tapchiyhcd.vn/index.php/yhcd/article/view/4860

CREATININE-TO-CYSTATIN C RATIO AND DISCORDANCE IN RENAL FUNCTION ASSESSMENT AMONG OUTPATIENTS WITH TYPE 2 DIABETES MELLITUS DURING ACUTE HYPERGLYCEMIA

Le Tuyet Minh Chau1, Tran Truong Trung Tinh1, Nguyen Tan Duc2, Le Quoc Tuan1
1 University of Medicine and Pharmacy at Ho Chi Minh city
2 Department of Biochemistry, Military Hospital 175

Main Article Content

Abstract

Objective: This study compared the creatinine-to-cystatin C ratio and examined its associations with metabolic characteristics and renal function in patients with and without acute hyperglycemia.


Methods: A case-control study was conducted in 76 outpatients with type 2 diabetes mellitus, including 38 patients with acute hyperglycemia (fasting glucose ≥ 180 mg/dL) and 38 patients age- and sex-matched stable controls. Variables included BMI, fasting glucose, HbA1c, serum creatinine, cystatin C, and urinary albumin-to-creatinine ratio. Estimated glomerular filtration rate (GFR) was calculated using the CKD-EPI (2021) creatinine equation and the CKD-EPI (2012) cystatin C equation. Pearson or Spearman correlation analyses were performed.


Results: The hyperglycemia group had higher BMI, HbA1c, creatinine, urinary albumin-to-creatinine ratio, and creatinine-to-cystatin C ratio, but lower cystatin C (p < 0.001). eGFR-Cre decreased, whereas eGFR-Cys increased compared with controls (p < 0.001). The creatinine-to-cystatin C ratio reversed its correlation with BMI between groups and was no longer associated with HbA1c or eGFR-Cre in the hyperglycemia group.


Conclusions: Acute hyperglycemia is associated with discordance between creatinine and cystatin C. The creatinine-to-cystatin C ratio may serve as an adjunctive marker for renal function assessment during acute metabolic stress.

Article Details

Keywords

Creatinine-to-cystatin C ratio, acute hyperglycemia, type 2 diabetes mellitus, renal function.

References

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