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Published: 2026-03-31
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DOI: https://doi.org/10.52163/yhc.v67i3.4600
Issue
Vol. 67 No. 3
Section
Articles
How to Cite
Linh, T. Đức, Linh, N. Đức, & Ba, N. V. (2026). QUALITY OF LIFE IN NON-SMALL CELL LUNG CANCER PATIENTS WITH BRAIN METASTASES AFTER TREATMENT WITH A COMBINATION OF GAMMA KNIFE RADIOSURGERY AND TKIs. Vietnam Journal of Community Medicine, 67(3). https://doi.org/10.52163/yhc.v67i3.4600

QUALITY OF LIFE IN NON-SMALL CELL LUNG CANCER PATIENTS WITH BRAIN METASTASES AFTER TREATMENT WITH A COMBINATION OF GAMMA KNIFE RADIOSURGERY AND TKIs

Tran Duc Linh1,2, Nguyen Duc Linh3,4, Nguyen Van Ba1,2
1 Military Medical Academy
2 Military Hospital 175
3 K Hospital
4 Hanoi Medical University

Main Article Content

Abstract

Objectives: To evaluate the changes in quality of life (QoL) in non-small cell lung cancer (NSCLC) patients with brain metastases after treatment with a combination of Gamma Knife radiosurgery and TKIs.


Subjects and methods: A longitudinal, prospective descriptive study was conducted on 43 NSCLC patients with brain metastases who received Gamma Knife radiosurgery combined with TKIs from January 2023 to December 2024.


Results: At the 6-month follow-up, most aspects of QoL remained stable. Several functions and symptoms showed significant improvement, such as: emotional function, fatigue, insomnia, future uncertainty, and motor dysfunction (improvement > 10 points, p<0,05). Meanwhile, rash and hair loss increased significantly. Patients with a low Karnofsky score and neurological symptoms before treatment showed better improvement in cognitive and motor functions (p<0,05). Meanwhile, patients treated with first and second generation TKIs developed skin rash more frequently than those treated with third generation TKIs (p=0.03).


Conclusion: The QoL of NSCLC patients with brain metastases after treatment with combined Gamma Knife radiosurgery and TKIs was maintained stably, with several functions and symptoms showing significant improvement.

Article Details

Keywords

Quality of life, Gamma Knife radiosurgery, TKIs, NSCLC, brain metastases.

References

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