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Published: 2026-08-25
Abstract Views: 22
DOI: https://doi.org/10.52163/yhc.v67iCD12.6287
Issue
Vol. 67 No. CĐ12- Bệnh viện Ung bướu Nghệ An
Section
Articles
How to Cite
Cương, N. B., Chiêm, L. Q., Anh, N. V. B., Anh, P. T. N., Thu, L. T. ., Anh, L. Q., Ban, N. N., Hùng, V. Đình, & Bình, V. Đức. (2026). CLINICAL AND LABORATORY PROFILES OF PATIENTS WITH PRIMARY MYELOFIBROSIS AT THE NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION BETWEEN 2019 AND 2024. Vietnam Journal of Community Medicine, 67(CĐ12- Bệnh viện Ung bướu Nghệ An). https://doi.org/10.52163/yhc.v67iCD12.6287

CLINICAL AND LABORATORY PROFILES OF PATIENTS WITH PRIMARY MYELOFIBROSIS AT THE NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION BETWEEN 2019 AND 2024

Nguyen Ba Cuong1, Le Quang Chiem1, Nguyen Vu Bao Anh1,2, Phi Thi Nguyet Anh1, Le Thi Thu1, Le Quoc Anh1, Nguyen Ngoc Ban3, Vu Dinh Hung3, Vu Duc Binh1,2
1 National Institute of Hematology and Blood Transfusion
2 Hanoi Medical University
3 National Institute of Hematology and Blood TransfusionNational Institute of Hematology and Blood Transfusion

Main Article Content

Abstract

Objective: To describle the clinical and laboratory profiles of patients with primary myelofibrosis (PMF) at the National Institute of Hematology and Blood Transfusion (NIHBT) between 2019 and 2024.


Methods: A cross-sectional descriptive study was conducted on 181 PMF patients managed at the NIHBT from January 2019 to December 2024.


Results: The cohort’s mean age was 62.7 ± 11.8 years, with a predominance of patients aged over 60. Constitutional symptoms were prevalent, including fatigue (89%), early satiety (70.2%), abdominal discomfort (70.2%), left upper quadrant pain (70.2%), and weight loss (63%). Physical examination revealed a high incidence of splenomegaly (95.6%) and anemia (89%).


Laboratory findings indicated that 90.6% of patients presented with anemia (Hb≤120 g/L). Platelet counts were variable: 26.5% exhibited thrombocytosis (≥450 G/L), while 14.9% had thrombocytopenia (< 50 G/L). Leukocytosis (≥11 G/L) was observed in 51.4% of the cases. Bone marrow evaluation showed erythroid hypoplasia in 85.6% of patients; granulocytic lineage was increased in 42.5% and decreased in 17.1%, while 73.5% demonstrated megakaryocytic hyperplasia. Bone marrow fibrosis was classified as Grade II in 64.6% and Grade III in 35.4% of patients. The prevalence of the JAK2 mutation was 67.1%, whereas CALR and MPL mutations were identified in 3.9% and 1.1% of the cohort, respectively.


Conclusion: Primary myelofibrosis patients present with heterogeneous clinical manifestations, characterized by high frequencies of splenomegaly and anemia. Laboratory analyses frequently reveal trilineage hematopoietic dysregulation in the bone marrow.

Article Details

Keywords

Primary myelofibrosis, National Institute of Hematology and Blood Transfusion, Vietnam.

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