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Published: 2026-07-25
Abstract Views: 9
DOI: https://doi.org/10.52163/yhc.v67i7.5995
Issue
Vol. 67 No. 7
Section
Articles
How to Cite
Trúc, T. T. T., Thảo, P. N. P., Trường, H., Trúc, T. T. T., & Nghĩa, H. Đặng T. (2026). ENTEROCOCCUS SPP. INFECTIONS AT THE HOSPITAL FOR TROPICAL DISEASES (2021 – 2023): EPIDEMIOLOGICAL CHARACTERISTICS, PATHOGENS, AND VANCOMYCIN RESISTANCE. Vietnam Journal of Community Medicine, 67(7). https://doi.org/10.52163/yhc.v67i7.5995

ENTEROCOCCUS SPP. INFECTIONS AT THE HOSPITAL FOR TROPICAL DISEASES (2021 – 2023): EPIDEMIOLOGICAL CHARACTERISTICS, PATHOGENS, AND VANCOMYCIN RESISTANCE

Tran Thanh Thuy Truc1, Phan Ngoc Phuong Thao2, Hoang Truong2, Tran Thanh Thien Truc2, Ho Dang Trung Nghia1,2
1 Hospital for Tropical Diseases
2 Pham Ngoc Thach University of Medicine

Main Article Content

Abstract

Methods: A descriptive cross-sectional study (retrospective and prospective) was conducted on 216 patients with Enterococcus spp. infections treated at the Hospital for Tropical Diseases from January 2021 to August 2023. Factors associated with vancomycin-resistant Enterococcus spp. (VRE) infection were identified using univariate and multivariate logistic regression models.


Results: Healthcare-associated infections due to Enterococcus spp. accounted for 87%, significantly outnumbering community-acquired infections, with the urinary tract being the most common infection site. E. faecium was the most prevalent pathogen (63%), followed by E. faecalis (36%). The overall rate of VRE infection was 34.3%, while E. faecium specifically showed a vancomycin resistance rate of 45.8%. Multivariate analysis revealed that patients aged ≥ 60 years had a significantly higher risk of VRE infection compared to those aged < 60 years (aOR = 1.91; 95% CI: 1.01–3.62). Diabetes mellitus (aOR = 2.00; 95% CI: 1.04–3.83) and a history of vancomycin use (aOR = 1.98; 95% CI: 1.04–3.76) were also identified as independent risk factors for VRE infection. The overall mortality rate in the study was 38.4%."


Conclusion: Enterococcus spp. infections pose a significant healthcare-associated burden, characterized by high mortality rates and the prevalence of vancomycin-resistant strains. VRE infection is independently associated with advanced age, diabetes mellitus and a history of prior vancomycin use.

Article Details

Keywords

Enterococcus spp.; VRE; vancomycin resistance; antibiotic resistance; nosocomial infection; healthcare-associated infection

References

[1] Byers, K. E., Anglim, A. M., Anneski, C. J., et al. (2001). A hospital epidemic of vancomycin-resistant Enterococcus: risk factors and control. Infection Control and Hospital Epidemiology, 22(3), 140–147. https://doi.org/10.1086/501880
[2] Diekema, D. J., Hsueh, P. R., Mendes, R. E., et al. (2019). The microbiology of bloodstream infection: 20-year trends from the SENTRY Antimicrobial Surveillance Program. Antimicrobial Agents and Chemotherapy, 63(7), e00355-19. https://doi.org/10.1128/AAC.00355-19
[3] Cheriyath, P., Prasad, A., Patel, P., et al. (2022). Measuring epidemiologic effects of Enterococcal bacteremia and outcomes From a nationwide inpatient sample database. Cureus, 14(7), e27516. https://doi.org/10.7759/cureus.27516
[4] Shrestha, S., Kharel, S., Homagain, S., et al. (2021). Prevalence of vancomycin-resistant enterococci in Asia - A systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics, 46(5), 1226–1237. https://doi.org/10.1111/jcpt.13383
[5] Kadri S. S. (2020). Key takeaways from the U.S. CDC's 2019 Antibiotic Resistance Threats Report for frontline providers. Critical Care Medicine, 48(7), 939–945. https://doi.org/10.1097/CCM.0000000000004371
[6] Phu, V. D., Wertheim, H. F. L., Larsson, M., et al. (2016). Burden of hospital acquired infections and antimicrobial use in Vietnamese adult intensive care units. PLOS ONE, 11(1), Article e0147544. https://doi.org/10.1371/journal.pone.0147544
[7] Nguyễn, N. H., Trần, C. D., & Hoàng, V. S. (2019). Khảo sát mối liên quan giữa đặc điểm vi sinh và kết quả điều trị ở bệnh nhân viêm nội tâm mạc nhiễm trùng. Tạp chí Tim mạch học Việt Nam, 88, 61–68
[8] Centers for Disease Control and Prevention. (2019). National Healthcare Safety Network (NHSN) patient safety component manual. U.S. Department of Health and Human Services. https://www.cdc.gov/nhsn/pdfs/validation/2019/pcsmanual_2019-508.pdf
[9] Li, J. S., Sexton, D. J., Mick, N., Nettles, R., Fowler, V. G., Jr., Ryan, T., Bashore, T. M., & Corey, G. R. (2000). Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clinical Infectious Diseases, 30(4), 633–638. https://doi.org/10.1086/313753
[10] Gedik, T., Kiraz, N., & Duran, H. (2023). The change of antibiotic resistance rates over the years in Enterococcus spp. isolated from clinical specimens. Journal of Health Sciences and Medicine, 6(5), 1052–1058. https://doi.org/10.32322/jhsm.1311029
[11] Pfaller, M. A., Cormican, M., Flamm, R. K., et al. (2019). Temporal and geographic variation in antimicrobial susceptibility and resistance patterns of Enterococci: results from the SENTRY Antimicrobial Surveillance Program, 1997-2016. Open Forum Infectious Diseases, 6(Suppl 1), S54–S62. https://doi.org/10.1093/ofid/ofy344