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Published: 2026-03-31
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DOI: https://doi.org/10.52163/yhc.v67i3.4635
Issue
Vol. 67 No. 3
Section
Articles
How to Cite
Quỳnh, N. T. N., Sơn, L. N. B., Phú, L. H., Tuấn, N. T. H., Ngân, N. H., Nhạn, L. T. T., Nam, N. T., & Tuấn, N. H. (2026). A COMPREHENSIVE REVIEW OF EXPERIMENTAL ANIMAL MODEL INDUCTION BASED ON SYNDROME DIFFERENTIATION IN TRADITIONAL CHINESE MEDICINE. Vietnam Journal of Community Medicine, 67(3). https://doi.org/10.52163/yhc.v67i3.4635

A COMPREHENSIVE REVIEW OF EXPERIMENTAL ANIMAL MODEL INDUCTION BASED ON SYNDROME DIFFERENTIATION IN TRADITIONAL CHINESE MEDICINE

Nguyen Thi Nhu Quynh1, Le Ngoc Bich Son2, Le Hong Phu3, Nguyen Thanh Ha Tuan4, Nguyen Hoang Ngan5, Le Thi Thanh Nhan6, Nguyen Truong Nam1, Nguyen Hoang Tuan7
1 Phenikaa University
2 Department of Traditional Medicine Management
3 Military Institute of Traditional Medicine
4 Học viện Quân y
5 Military Medical Academy
6 Faculty of Medicine - Hanoi University of Business and Technology
7 High School for Gifted Students in Natural Sciences, Vietnam National University, Hanoi

Main Article Content

Abstract

Objective: To classify and synthesize methods for establishing experimental animal models based on syndrome differentiation in traditional medicine.


Methodology: This study was conducted as a scoping review in accordance with the PRISMA-ScR guidelines. Literature was searched in PubMed, CNKI, and Google Scholar from January 2004 to June 2025. Extracted data included animal species/strains, induction interventions, syndrome validation criteria, objective outcome measures.


Results: Of the 40 records initially identified, 18 articles were assessed in full text, and 16 experimental studies met the eligibility criteria. Integrated disease–syndrome models were the most prevalent (n = 7, 43.7%), followed by conversion models (n = 5, 31.3%) and syndrome-only models (n = 4, 25%).


Conclusion: Experimental animal models based on TCM syndromes have increasingly evolved toward integrated disease–syndrome models, supporting research on integrated traditional and modern medicine. No eligible Vietnam-based publications were identified within the specified search strategy.

Article Details

Keywords

Animal model, Traditional Chinese Medicine syndrome, disease-syndrome model, Zheng-hou (syndrome pattern), modeling methods.

References

[1]. Ling, S., & Xu, J.-W. (2013). Model organisms and traditional Chinese medicine syndrome models. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 761987. doi.org/10.1155/2013/761987

[2]. 李缘缘, 高碧珍. 中医证动物模型的发展现状、问题与对策思考[J]. 中华中医药杂, 2024, 39(1): 49–53.
[3]. Li L，Liu JX，Ren JG，et al. Research status and perspective of animal models in research and development traditional Chinese medicine [J]. Chin J Comp Med，2022，32(1): 104-110. doi:10.3969/j.issn.1671-7856.2022.01.014
[4]. 高振. 中医证候模型: 从定位基础到模拟临床. 中国中医基础医学杂志, 2020, 26(11): 1546–1548.
[5]. 杜利莉. 中医证候动物模型建立及评价方法研究. 中医药导报, 2025, 41(1):11-18. doi:10.14148/j.issn.1672-0482.2025.0011