NEUROGENETICS OVERVIEW OF MENTAL HEALTH DISORDERS: SCHIZOPHRENIA, BIPOLAR DISORDER, AND DEPRESSION
Main Article Content
Abstract
ABSTRACT
Objective:
To provide a structured narrative review of updated evidence on the neurogenetics of common mental health disorders, specifically schizophrenia, bipolar disorder, and depression.
Method:
A structured narrative review was conducted by identifying high-impact studies from 2021-2025 via PubMed and Google Scholar. Ten selected articles focusing on genome-wide association studies (GWAS), polygenic risk scores (PRS), and gene-environment interactions were synthesized to come to conclusions on the neurogenetic architecture of these disorders.
Result:
Mental health disorders, particularly the three studied, are formed by a complex polygenic architecture. Genetic variations contribute to biological vulnerability, which, when interacting with adverse environmental factors and psychological resilience, can trigger or exacerbate symptoms through changes in neural structure and function.
Conclusion:
Understanding of neurogenetics not only clarifies aspects of disease causation but also supports mental health’s early diagnosis and personalized medicine.
Article Details
Keywords
Neurogenetics; mental health disorders; schizophrenia; bipolar disorder; depression; movement-environment interactions; personalized medicine.
References
[2] Kato H, Kimura H, Kushima I, Takahashi N, Aleksic B, Ozaki N. The genetic architecture of schizophrenia: review of large-scale genetic studies. J Hum Genet. 2023;68(3):175-182. https://doi.org/10.1038/s10038-022-01059-4
[3] Peedicayil J. Genome-Environment Interactions and Psychiatric Disorders. Biomedicines. 2023;11(4):1209. https://doi.org/10.3390/biomedicines11041209
[4] Forero DA. Genomics of psychiatric disorders: Regional challenges and opportunities. Biomedica. 2023;43(1):5-7. https://doi.org/10.7705/biomedica.6996
[5] Tian H, Hu Z, Xu J, Wang C. The molecular pathophysiology of depression and the new therapeutics. MedComm. 2022;3(3):e156. https://doi.org/10.1002/mco2.156
[6] Wahbeh MH, Avramopoulos D. Gene-Environment Interactions in Schizophrenia: A Literature Review. Genes (Basel). 2021;12(12):1850. https://doi.org/10.3390/genes12121850
[7] Owen MJ, Legge SE, Rees E, Walters JTR, O'Donovan MC. Genomic findings in schizophrenia and their implications. Mol Psychiatry. 2023;28(9):3638-3647. https://doi.org/10.1038/s41380-023-02293-8
[8] Robinson N, Bergen SE. Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions. Front Genet. 2021;12:686666. https://doi.org/10.3389/fgene.2021.686666
[9] Remes O, Mendes JF, Templeton P. Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature. Brain Sci. 2021;11(12):1633. https://doi.org/10.3390/brainsci11121633
[10] Alshaya DS. Genetic and epigenetic factors associated with depression: An updated overview. Saudi J Biol Sci. 2022;29(8):103311. https://doi.org/10.1016/j.sjbs.2022.103311