MỘT SỐ ĐỘC TÍNH CẤP, BIẾN CHỨNG SAU MỘT THÁNG VÀ KẾT QUẢ HÓA XẠ TRỊ ĐỒNG THỜI UNG THƯ VÒM MŨI HỌNG BẰNG KỸ THUẬT XẠ TRỊ ĐIỀU BIẾN LIỀU TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Objective: To describe the incidence of acute toxicities, complications after one month follow-up, and treatment outcomes of concurrent chemoradiotherapy for nasopharyngeal carcinoma using intensity-modulated radiation therapy (IMRT) at Thai Nguyen Central General Hospital.

Materials and Methods: A longitudinal descriptive study was conducted on 53 patients diagnosed with nasopharyngeal carcinoma who received concurrent chemoradiotherapy at Thai Nguyen Central General Hospital between June 2022 and June 2025.

Results: Patients aged 50–59 years accounted for the highest proportion (30.8%), with a mean age of 53.6 ± 11.6 years. Stage III disease was the most common (66.0%). The most frequent acute hematologic toxicity was leukopenia, with grade 1, 2, and 3 incidences of 41.5%; 28.3%; 5.7%, respectively. The predominant renal toxicity was grade 1 creatinine elevation (35.8%). Oral mucositis occurred in 71.7% of patients, mostly grade 1. At one month after completion of concurrent chemoradiotherapy, hearing loss was the most common late complication, observed in 77.4% of patients, with grade 1 accounting for the majority (56.6%). Trismus was reported in 5.7% of patients. A complete response was achieved in 71.7% of cases, while 28.3% achieved a partial response. No disease progression was recorded.