36. CLINICAL FEATURES ACCORDING TO HISTOPATHOLOGICAL LESIONS OF CHRONIC GASTRITIS AND RISK FACTORS OF HELICOBACTER PYLORY INFECTION IN CHILDREN AT NGHE AN OBSTERTRIC AND PEDIATRIC HOSPITAL.
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Abstract
Abstract: Chronic gastritis caused by Helicobacter pylori (H. pylori) is a public health problem. Histopathological test of gastric mucosa biopsies is an important role in the diagnosis of chronic gastritis and H. pylori infection. Objectives: Describe the clinical characteristics according to histopathological lesions of chronic gastritis with H. pylori infection in children at Nghe An Obstetric & Pediatric Hospital.
Subjects and methods: A cross-sectional description study on 238 patients diagnosed with chronic gastritis: 119 patients infected H. pylori and 119 patients not infected H. pylori at Nghe An Obstetric & Pediatric Hospital from 01/2023 to 09/2023. Results: In 119 patients infected H. pylori: Female/male ratio = 1.1/1, mean age: 9.3 ± 2.7 years (3 - 15 years). Histopathology results: H. pylori infection: 42.4% mild. Inflammation level: 58.9% moderate. Activity level: 18.8% severe, 45.9% mild activity. Belching - heartburn, and gastrointestinal bleeding were higher in the severe H. pylori infection group (OR: 8.77 and 8.77), severe inflammation (OR: 8.17 and 6.00), and severe activity (OR: 3.46 and 3.60). Factors related to H. pylori infection: Risk factors increase H. pylori infection in children with chronic gastritis at Nghe An Obstetrics and Pediatrics Hospital are cramped house space (OR = 2.1, 95%CI: 1.2-3.6), starting school early (OR = 2.5, 95%CI: 1.4-4.5), early weaning from breastfeeding (OR = 1.8, 95%CI: 1.1-3.1), maternal history of H. pylori infection (OR = 4.8, 95%CI: 2.7-8.2), while neither parent was infected with H. pylori was a protective factor that reduced the rate of H. pylori infection (OR = 0.3, 95%CI: 0.2-0.6). Conclusions: Most of patients have mild H. pylori infection, moderate chronic gastritis, mild activity. Belching - heartburn, gastrointestinal bleeding were higher in the group of severe H. pylori infections, severe inflammation, and severe activity. Risk factors that increase H. pylori infection in children with chronic gastritis are small house space, starting school early, early weaning from breastfeeding, mother's history of H. pylori infection, while both parents are not infected with H. pylori is a protective factor.
Article Details
Keywords
Chronic gastritis, H. pylori, histopathology
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