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Published: 2025-05-31
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DOI: https://doi.org/10.52163/yhc.v66iCD6.2275
Issue
Tập 66 Số CĐ6 - HNKH Bệnh viện Sản Nhi Nghệ An
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Articles
How to Cite
Mười, H. Đăng ., Nguyệt, L. T., & Cảnh, N. T. (2025). 13. CLINICAL AND PARACLINICAL CHARACTERISTICS AND STUDY SOME RISK FACTORS FOR DRUG RESISTANCE IN THE TREATMENT OF DRUG-RESISTANT EPILEPSY IN CHILDREN AT NGHE AN OBSTETRICS AND PEDIATRICS HOSPITAL. Vietnam Journal of Community Medicine, 66(CD6). https://doi.org/10.52163/yhc.v66iCD6.2275

13. CLINICAL AND PARACLINICAL CHARACTERISTICS AND STUDY SOME RISK FACTORS FOR DRUG RESISTANCE IN THE TREATMENT OF DRUG-RESISTANT EPILEPSY IN CHILDREN AT NGHE AN OBSTETRICS AND PEDIATRICS HOSPITAL

Ho Dang Muoi1, Le Thi Nguyet1, Nguyen Thi Canh1
1 Nghe An Obstetric and Pediatric Hospital

Main Article Content

Abstract

Objectives: Describe clinical and paraclinical characteristics and study some risk factors for drug resistance in the treatment of drug-resistant epilepsy in children.


Subjects and methods: Cross-sectional descriptive study on 96 children with epilepsy treated as outpatients and inpatients at the Department of Neurology, Nghe An Obstetrics and Pediatrics Hospital from January 2024 to October 2024, divided into 2 groups: drug-resistant epilepsy (n = 41) and drug-responsive (n = 55). Patients were diagnosed with drug-resistant epilepsy and drug-responsive according to the International League Against Epilepsy (ILAE 2010) criteria.


Results: 96 children with epilepsy included 47 females (49%) and 49 males (51%). Drug-resistant epilepsy in the group of children with a history of status epilepticus accounted for 31.7%, a history of neonatal seizures accounted for 43.9%, a history of febrile seizures accounted for 56.1%, and a history of delayed psychomotor milestones accounted for 92.7%. The average age of onset in the drug-resistant epilepsy group was 10.66 ± 13.0 months, and the average seizure frequency in the drug-resistant epilepsy group per day was 12.12 ± 8.4. The results of paraclinical analysis of EEG and abnormal brain MRI in the drug-resistant epilepsy group accounted for 85.4% and 48.8%, respectively. Multivariate regression analysis showed that a history of neonatal seizures, a history of febrile seizures, status epilepticus, delayed psychomotor milestones, abnormal EEG and MRI were factors related to drug-resistant epilepsy.


Conclusion: The medical history, clinical and paraclinical characteristics in epilepsy including history of neonatal seizures, history of febrile seizures, status epilepticus, delayed psychomotor development, abnormal EEG and MRI are factors related to drug-resistant epilepsy

Article Details

Keywords

Childhood, epilepsy, drug-resistant epilepsy

References

[1] 1. Berg A.T. và Rychlik K. (2015). The course of childhood-onset epilepsy over the first two decades: a prospective, longitudinal study. Epilepsia, 56(1), 40–48.
[2] 2. Kwan P., Arzimanoglou A., Berg A.T. (2010). Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), 1069–1077.
[3] 3. Tang F., Hartz A.M.S., và Bauer B. (2017). Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers. Frontiers in Neurology, 8.
[4] 4. Trinka E., Bauer G., Oberaigner W. (2013). Cause-specific mortality among patients with epilepsy: Results from a 30-year cohort study. Epilepsia, 54(3), 495–501.
[5] 5. Vickers N.J. (2017). Animal communication: when i’m calling you, will you answer too? Current biology, 27(14), R713–R715.
[6] 6. Boonluksiri P., Visuthibhan A., và Katanyuwong K. (2015). Clinical Prediction Rule of Drug Resistant Epilepsy in Children. J Epilepsy Res, 5(2), 84–88.
[7] 7. Nguyễn Thụy Minh Thư, Nguyễn Lê Trung Hiếu. (2021.) Mức độ khả thi, an toàn và hiệu quả của chế độ ăn Ketogenic trên bệnh nhân động kinh kháng thuốc tại bệnh viện Nhi Đồng 2. Tạp chí Y học TP Hồ Chí Minh, tập 25, số 2.
[8] 8. Kwan P., Arzimanoglou A., Berg A.T. (2010). Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
[9] 9. Karaoğlu P., Yi̇Ş U., Polat A.İ. (2021). Clinical predictors of drug-resistant epilepsy in children. Turk J Med Sci, 51(3), 1249–1252.
[10] 10. Đặng Anh Tuấn (2018). Nghiên cứu lâm sàng, tổn thương não và các yếu tố liên quan đến động kinh cục bộ kháng thuốc ở trẻ em. Luận án tiến sỹ y học, Đại Học Y Hà Nội.