DEHEMA is an herbal product developed from the ancient remedy “Tao Hong Si Wu Tang”, clinically prescribed for blood stasis syndrome caused by injury, contusion or surgeries.
Objectives: To evaluate the analgesic effects of DEHEMA in experimental animals.
Methods: The study was conducted using three animal models: hot plate test, Von Frey test and acetic acid-induced writhing test. Mice were divided into five groups and were orally administered: group 1 distilled water; group 2 paracetamol combined with tramadol; groups 3 diclofenac; group 4 DEHEMA high dose of 48mL/kg b.w./day; group 5 DEHEMA low dose of 24mL/kg b.w./day.
Results: The DEHEMA groups showed a tendency in prolonging the heat response time in the hot plate model; prolonging the response time to pain stimuli and increasing force required to elicit pain in Von Frey test; delaying the onset time and reducing the number of writhing in acetic acid-induced writhing model.
Conclusions: This study’s findings suggest the potential analgesic effects of DEHEMA in experimental models.