Bài báo khoa học Tập 65 Số Tiếng Anh 12/12/2024

10. EVALUATION OF THE EFFICACY AND SAFETY FOR THE COMBINATION USE OF ORAL AND TOPICAL TRANEXAMIC ACID IN THE TREATMENT OF MELASMA AT HO CHI MINH CITY DERMATOLOGY HOSPITAL

Tang Kha Tu1, Tran Nguyen Anh Tu2, Nguyen Trong Hao1
1 Pham Ngoc Thach University of Medicine
2 Ho Chi Minh City Hospital of Dermato-Venereology
Tác giả liên hệ: Khatuyds@gmail.com
DOI: 10.52163/yhc.v65i13.1792
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Từ khóa
tranexamic acid oral and topical melasma
Tóm tắt

Objective: To evaluate the effectiveness and safety of oral and topical tranexamic acid in the treatment of melasma.

Subjects and methods: A descriptive study of a series of cases with longitudinal follow-up was conducted on 28 female patients with melasma at the Ho Chi Minh City Dermatology Hospital from April 2024 to August 2024.

Results: The study subjects had an average age of 47.46 ± 8.23 (34 - 63) years old, 78.57% had a family history of melasma. The assessment of melasma improvement according to the PGA scale showed that 100% of patients had melasma improvement of over 25% (50.00% had good improvement of 51-75%). MASI index had a significant improvement after treatment compared to before treatment with statistical significance with p<0.001. All patients were satisfied after treatment with 57.14% of patients being very satisfied, 92.86% having no side effects.

Conclusion: Oral and topical tranexamic acid is an effective and safe method for treating melasma.

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