Bài báo khoa học Tập 65 Số Tiếng Anh 12/12/2024

4. THE NUTRITIONAL STATUS OF PATIENTS WITH BETA THALASSEMIA MAJOR: A SCOPING REVIEW

Hoang Thi Ngoc Anh1, Dinh Thi Thu Trang1, Nguyen Hoang Long1, Tran Quoc Thang1,2, Dao Van Dung1, Pham Van Thao1, Ta Thi Kim Lien1, Bui Thi Mai An1
1 Phenikaa University
2 Institude of Community Health
Tác giả liên hệ: anh.hoangthingoc@phenikaa-uni.edu.vn
DOI: 10.52163/yhc.v65i13.1725
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Từ khóa
nutritional status patient beta thalassemia major scoping review malnutrition
Tóm tắt

Objective: This study aimed to review and summarize the existing evidence on the nutritional status of patients with beta thalassemia major.

Methods: A scoping review was conducted using the Medline database via PubMed. Seven studies from six countries, involving 836 participants, met the inclusion criteria. Data were extracted on anthropometric measurements, body composition, laboratory indicators, and dietary intake.

Results: The findings indicated a high prevalence of malnutrition, particularly among children with beta thalassemia major. Anthropometric data showed significantly lower weight, height, and body mass index compared to healthy individuals. Body composition analysis revealed lower fat percentages and higher muscle mass in children, while adults exhibited decreased lean mass and increased fat mass, with 64.2% classified as obese with sarcopenia. Laboratory results showed deficiencies in serum vitamin D and cholesterol, though calcium and phosphorus levels remained normal. Dietary intake assessments revealed inadequate energy and nutrient intake, particularly for macronutrients and key micronutrients such as calcium, phosphorus, and zinc.

Conclusion: Patients with beta-thalassemia major are at high risk of malnutrition, which is associated with both disease and treatment factors. Routine nutritional assessments and tailored interventions are critical for improving the nutritional status and overall health outcomes of this vulnerable population.

Tài liệu tham khảo
[1]
EB F. The importance of nutrition for health in patients with transfusion-dependent thalassemia. Ann N Y Acad Sci. 2016;1368(1):40-8. Google Scholar
[2]
Goldberg EK NS, Lal A, Higa A, Fung E. Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload. J Food Nutr Res (Newark). 2018;6(10):674-81. Google Scholar
[3]
Schnedl WJ SM, Lackner S, Holasek SJ, Mangge H. β-thalassemia minor, carbohydrate malabsorption and histamine intolerance. J Community Hosp Intern Med Perspect. 2017;7(4):227-9. Google Scholar
[4]
Rosen CJ KA. Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis. Am J Med. 2009;122(5):409-14. Google Scholar
[5]
Lidoriki I SG, Schizas D, Frountzas M, Fotis L, Kapelouzou A, Kokkota S, Fyntanidou B, Kotzampassi K. Nutritional Status in a Sample Google Scholar
[6]
of Patients With β-Thalassemia Major. Cureus. Google Scholar
[7]
;14(8):e27985. Google Scholar
[8]
Elalfy MS EF, El Gendy YG, Zaki MM, Kalifa Google Scholar
[9]
ASA. Body Composition in Egyptian Children Google Scholar
[10]
With Transfusion-dependent Thalassemia: The Google Scholar
[11]
Impact of Nutrition and Metabolic Profile. J Pediatr Hematol Oncol. 2020;42(5):e334-e9. Google Scholar
[12]
Fahim FM SK, Askar EA, Eldin EN, Thabet AF. Google Scholar
[13]
Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt. Int Google Scholar
[14]
J Hematol Oncol Stem Cell Res. 2013;7(4):10-4. Google Scholar
[15]
G AC. Is CONUT score a predictor of morbidity in patients with adult transfusion dependent beta thalassemia? Transfus Apher Sci. Google Scholar
[16]
;60(4):103126. Google Scholar
[17]
P T. Effect of nutrition support on immunity in Google Scholar
[18]
paediatric patients with beta-thalassaemia major. Google Scholar
[19]
Asia Pac J Clin Nutr. 2003;12(1):61-5. Google Scholar