Bài báo khoa học Tập 65 Số Tiếng Anh 12/12/2024

1. COMBINATION OF TRADITIONAL CO2 LASER AND PULSE DOSES ITRACONAZOLE IN PRIMARY TOTAL DYSTROPHIC ONYCHOMYCOSIS (TDO) TREATMENT: A CASE REPORT

Ngo Minh Thao1, Le Huu Doanh2
1 National Hospital of Dermato-Venereology
2 Hanoi Medical University
Tác giả liên hệ: ngothao2609.hmu@gmail.com
DOI: 10.52163/yhc.v65i13.1722
22 Lượt xem
38 Lượt tải xuống
Từ khóa
Onychomycosis CO2 laser ablative oral itraconazole pulse doses intermittent dosing
Tóm tắt

Onychomycosis is one of the most common nail diseases. Treatment of onychomycosis, mainly moderate to severe, can be very challenging, expensive and time consuming. Compared with topical and oral therapies, laser treatment offers a more promising modality for the treatment of severe or resistant cases. To enhance the effect, the combination of oral itraconazole pulse doses with mechanical removal of the affected part of the nail plate by using ablative CO2 laser are investigated. Here, we report a total dystrophic onychomycosis case successfully treated with traditional CO 2 laser and pulse doses itraconazole. This suggests the potential of conventional ablative CO 2 laser in the treatment of severe onychomycosis.

Tài liệu tham khảo
[1]
Gasser J., Pagani E., Vittadello F., al e. Frequency, type and treatment of fungal pathogens in toenail onychomycosis in the central alpine region of South Tyrol, northern Italy: a 10-year retrospective study from 2004 to 2013. Mycoses. 2016;59(12):760-764. Google Scholar
[2]
Lipner S.R., R.K. S. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80(4):835-851. Google Scholar
[3]
Drake L.A., Pattrick D.L., Fleckman P., al e. The impact of onychomycosis on quality of life: Development of an international onychomycosisspecific questionnaire to measure patients quality of life. J Am Acad Dermatol. 2000;41(2):189-196. Google Scholar
[4]
Gupta A.K., Daigle D., J.L. C. The role of biofilms in onychomycosis. J Am Acad Dermatol. 2016;74(6):1241-1246. Google Scholar
[5]
Ma W, Si C, Zhou B, al e. Laser treatment for onychomycosis. Medicine. 2019;98(48). Google Scholar
[6]
Ameen M., Lear J.T., Madan V., al e. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. British Google Scholar
[7]
Journal of Dermatology. 2014;171:937-958. Google Scholar
[8]
J.F. L. The observation of efficacy of 26 cases of CO2 laser treatment for onychomycosis. Chin J Mycol. 2008;3:289-291. Google Scholar
[9]
Yang Y, Liu H, Yang RY, al e. The observation of efficacy of Ultrapulse CO2 fractional laser treatment for onychomycosis. Chin J Dermatol. 2015:526-530. Google Scholar
[10]
Cheng YR, Wang CY, Cao LF, al e. Clinical observation of CO2 laser treatment for onychomycosis. Chin J Dermatovenereol. 1997:53-54. Google Scholar
[11]
Xu J, Zhuo FL, Zhang RN, al e. The progress in laser treatment for onychomycosis. Chin J Laser Med Surg. 2013:41-44. Google Scholar