35. CHARACTERISTICS OF MOLECULAR SUBTYPES OF BREAST CANCER AT THONG NHAT HOSPITAL
Main Article Content
Abstract
Introduction: A comprehensive understanding of the molecular characteristics of breast cancer is crucial for the development of more effective diagnostic and therapeutic strategies. Molecular classification of breast cancer provides valuable insights that can guide treatment decisions.
Methods: This study involved a cross-sectional description of invasive breast carcinoma cases treated at Thong Nhat Hospital in 2023. Histopathological evaluation and molecular subtyping were performed based on immunohistochemistry of ER, PR, HER2, and Ki-67 markers.
Results: In our 2023 study of 49 cases of breast carcinoma at Thong Nhat Hospital, the following distribution was observed: Luminal B subtype predominates with a rate of 55.1%. Luminal A subtype accounted for 28.6%. Triple-negative subtype: 8.2% HER2 subtype: 8.2%. Statistical analysis revealed a significant correlation between molecular subtype characteristics and the Ki-67 proliferation index (p<0.001). Triple-negative and HER2 subtypes exhibited a high Ki-67 mitotic index. No significant association was found between molecular subtypes and patient age or histological grade.
Conclusion: The molecular subtyping of breast cancer plays a crucial role in selecting precise and personalized treatment methods for each patient. Personalized treatment includes endocrine therapy and may consider adding neoadjuvant chemotherapy or targeted drugs to achieve the best treatment outcomes for the patient.
Article Details
Keywords
Invasive breast carcinoma, immunohistochemistry, molecular subtype, HER2, ER, PR, Ki67
References
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