Articles Vol. 65 No. 2 08/03/2024

32. ASSESSMENT OF CHANGES IN FOLLICLE-STIMULATING HORMONE, LUTEINIZING HORMONE, PROLACTIN CONCENTRATIONS IN FEMALE PATIENTS WITH SEVERE ACNE VULGARIS TREATMENT WITH ISOTRETINOIN

Trinh Thu Huyen1,2, Nguyen Thi Kim Tien3,4, Hoang Hong Manh3,4, Vu Huy Luong1,2, Do Thi Thu Hien5,6
1 Hanoi Medical University
2 Trường Đại học Y Hà Nội
3 VNU University of Medicine and Pharmacy
4 Trường Đại học Y Dược - Đại học Quốc gia Hà Nội
5 National Hospital of Dermatology and Venereology
6 Bệnh viện Da liễu Trung ương
Corresponding author: thuhuyen1991fpt@gmail.com
DOI: 10.52163/yhc.v65i2.951
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Keywords
Acne vulgaris, FSH, GAGS, isotretinoin, LH, prolactin.
Abstract

Objective: Evaluate the effects of isotretinoin on FSH, LH, and prolactin hormone levels in female patients with severe acne vulgaris.

Research subjects and methods: Clinical trial, prospective, comparing results before and after 3 months of treating severe acne vulgaris with isotretinoin 20 mg/day on 45 female patients at the National Dermatology Hospital from October 2022 to September 2023.

Results: Before treatment, the rate of change in FSH, LH and prolactin levels was 6,7%; 8,9%; 13,3%, after treatment this rate of change tends to decrease to 6,7%; 4,4%; 2,2%. Although this change is not statistically significant with P>0,05, when evaluating the average concentration of hormones, it is found that: FSH decreased from 5,4±1,8 mIU/mL to 5±1,6 mIU/mL, P =0,03; LH decreased from 8±3,3 mIU/mL to 7,6±2,9 mIU/mL, P=0,04; prolactin decreased from 384,6±167,2 mIU/mL to 347,8±133,9 mIU/mL, P<0,01.

Conclusion: Treatment of severe acne vulgaris in female patients with isotretinoin 20 mg/day reduces the average concentrations of hormones FSH, LH and prolactin.

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