Articles Vol. 65 No. 2 08/03/2024

30. CHARACTERISTICS OF BIOMARKERS IN PREGNANCY SCREENING OF DOWN SYNDROME IN THE FIRST TRIMESTER OF PREGNANCY AT THE NATIONAL HOSPITAL OF OBSTETRICS AND GYNECOLOGY

Le Thi Minh Phuong1,2, Tran Danh Cuong3,4, Nguyen Thi Trang5,6, Ngo Toan Anh3,4, Vu Van Nga1,2, Do Thi Quynh1,2, Le Pham Sy Cuong3,4, Luong Thi Phuong Anh1,2
1 VNU University of Medicine and Pharmacy
2 Trường Đại học Y Dược - Đại học Quốc gia Hà Nội
3 National Hospital of Obstetrics and Gynecology
4 Bệnh viện Phụ sản Trung ương
5 Hanoi Medical University
6 Trường Đại học Y Hà Nội
Corresponding author: phuongltm.ump@vnu.edu.vn
DOI: 10.52163/yhc.v65i2.949
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Keywords
Down Syndrome, Prenatal screening, PAPP-A; free β-hCG; nuchal translucency (NT).
Abstract

Objective: Characteristics of some biomarkers related to prenatal screening in the first trimester of pregnancy at the National Hospital of Obstetrics and Gynecology.

Methods: Cross-sectional descriptive study based on 319 records of pregnant women meeting the criteria with gestational age from 11 weeks to 13 weeks 6 days.

Results: The distribution of MoM PAPP-A indices in the group of fetuses with Down syndrome concentrated mainly in the very lower value range while there was no difference in MoM fbHCG between these two groups. The cut-off threshold for the NT is 2.47mm. The cut-off values of MoM fβ-hCG and MoM PAPP-A were 2.485 and 0.657, respectively. NT and MoM fβ-hCG increase above the threshold value, and MoM PAPP-A decreases below the threshold value, increasing the possibility of pregnancy with Down syndrome.

Conclusions: Simultaneous biochemical testing and ultrasound are necessary for prenatal screening of Down syndrome in the first trimester of pregnancy.

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