Articles Vol. 65 No. 2 08/03/2024

27. THE EFFECT OF INHIBITING BENIGN PROSTATIC HYPERPLASIA OF “TLT-BCA” PILLS ON EXPERIMENT

Nguyen Duy Hoan1,2, Pham Ba Tuyen3,4, Nguyen Truong Nam5,6, Nguyen Thi Lien7,8
1 Vietnam University Of Traditional Medicine & Pharmacy
2 Học viện Y dược học Cổ truyền Việt Nam
3 Traditional Medicine Hospital, Ministry of Public Security
4 Bệnh viện Y học cổ truyền, Bộ Công an
5 Phenikaa University
6 Đại học Phenikaa
7 Rang Dong light source and vacuum flask joint stock Company
8 Công ty Cổ phần Bóng đèn Phích nước Rạng Đông
Corresponding author: nam.nguyentruong@phenikaa-uni.edu.vn
DOI: 10.52163/yhc.v65i2.946
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Keywords
Benign prostatic hyperplasia, wistar rat, “TLT-BCA”.
Abstract

Objectives: To evaluate the effect of “TLT-BCA” pills on inhibiting benign prostatic hyperplasia induced by testosterone propionate (TP) in Wistar rats.

Subjects and methods: Wistar rats were injected subcutaneously with TP at a dose of 3mg/kg/24h or with sesame oil (physiological control group), and given “TLT-BCA” (treatment 1 and 2 groups), Dutasteride (reference group) or physiological saline (physiological control and pathological control groups) for 28 consecutive days.

Results: “TLT-BCA” pills at dose 700mg/kg/24h and 2100mg/kg/24h reduced prostate weight, decreased MDA concentration in both blood and prostate tissue of rats (p < 0.01 compared to the pathology).

Conclusions: “TLT-BCA” pills have reduced prostate weight on the model of benign prostatic hyperplasia in Wistar rats. The mechanism of action may be involved in the antioxidant effects.

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