Articles Vol. 65 No. 1 18/01/2024

33. ASSESSMENT CONCENTRATION OF D-DIMER AND SOME RELATED FACTORS IN PATIENTS RECOVERED FROM COVID-19 DISEASE

Nguyen Vu Lam Yen1,2, Vu Huynh Tra My1,2, Tran Huu Tam1,2, Le Van Chuong3,4
1 Pham Ngoc Thach University of Medicine
2 Trường Đại học Y Khoa Phạm Ngọc Thạch
3 University of Medicine and Pharmacy at Ho Chi Minh City
4 Đại học Y Dược Thành phố Hồ Chí Minh
Corresponding author: chuongmedtech@ump.edu.vn
DOI: 10.52163/yhc.v65i1.907
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Keywords
Post-Covid-19 patients, D-dimer concentrations, hypercoagulability.
Abstract

Objective: Describe D-dimer concentrations and analyze factors related to hypercoagulability in post-Covid-19 patients at Dai Phuoc General Clinic.

Subject and method: Retrospectively performed records of 457 patients who had been infected with Covid-19 and had results of quantification of D-dimer concentrations at Dai Phuoc General Clinic from June to July 2022.

Results: 371/457 subjects (81.2%) had D-dimer concentrations < 500 ng/mL and 86/457 subjects had D-dimer concentrations ≥ 500 ng/mL (18.8%). The women have higher D-dimer concentrations than men (z = 5.037, p (sig. (2-sided test)) < 0.05). Patients ≥ 60 years old had higher D-dimer concentrations than those under 60 years old (z = 7,243, p (sig (2-sided test)) < 0.05). Patients with medical conditions were also reported to have higher D-dimer levels than patients without medical conditions (z = 2,999, p (sig (2-sided test)) < 0.05).

Conclusion: Although they have recovered from Covid-19, there is still a fairly high proportion of survey subjects with D-dimer levels higher than the normal threshold, posing a potential risk of hemostatic disorders in post Covid-19 patients. In addition, the study also showed that the group of subjects with abnormal D-dimer concentrations was related to factors such as female gender, age ≥ 60 and comorbidities. Therefore, it is necessary to periodically monitor and screen post Covid-19 people, especially in high-risk groups.

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