Articles Vol. 64 No. 5 23/08/2023

26. ANALYSIS OF SOME HEMATOLOGICAL AND IMMUNOLOGICAL PARAMETERS IN FULL TERM NEONATES WITH SEPSIS AT VIETNAM NATIONAL CHILDREN'S HOSPITAL, 2020

Nguyen Hong Truong1,2, Hoang Dinh Canh3,4
1 Vinh General Hospital
2 Bệnh viện Đa khoa Vinh
3 National Institute of Malariology, Parasitology and Entomology
4 Viện Sốt rét - Ký sinh trùng - Côn trùng Trung ương
Corresponding author: bstruongbvtp@gmail.com
DOI: 10.52163/yhc.v64i5.783
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Keywords
Sepsis, neonates, full term.
Abstract

Objectives: The study was conducted to determine the biochemical and hematological parameters in full-term neonates with sepsis in order to evaluate the role of these parameters in sepsis diagnosis.

Study methods: The study was designed using experimental descriptive method at the laboratory.

Results: The mean Hct in the full-term neonates with sepsis was 40.3% ± 7.3%. The overall Hct deficiency was 72.9% (62/85). The overall increased white blood cell count was 41.2%. The mean white blood cell count per litre of peripheral blood was 16.78 ± 10.31 (109/L). The mean white blood cell count in the term neonates with sepsis caused by Gram positive bacteria, Gram negative bacteria, and fungi was 19.48 ± 11.22, 19.97 ± 13.45, 17.17 ± 10.05 respectively. The difference was not statistically significant in the mean value of white blood cell count in each etiology with 19.48 ± 11.22 of S. aureus, 19.48 ± 11.22 of K. pneumonia, 19.97 ± 13.45 of E.coli, 17.17 ± 10.05 of agalactiae, 11.75 ± 7.46 of Candida and 17.42 ± 10.80 of other causes, p > 0.05. The average number of platelets in the blood was 211.69 ± 204.45, and 49.6% of the neonates had thrombocytopenia (platelets < 100x109/L). The mean blood CRP was 84.2 ± 76.8 mg/L, and 88.3% (75/85) of the neonates had an increased CRP.

Conclusions: The mean Hct in the full-term neonates with sepsis was 40.3% ± 7.3%. The overall Hct deficiency was 72.9%. The rate of increased white blood cell count was 41.2%. The mean white blood cell count per litre of blood was 16.78 ± 10.31. The mean platelet count in the blood was 211.69 ± 204.45, with 49.6% of thrombocytopenia. The increased CRP was 88.3%.

References
[1]
WHO, Neurocognitive impairment Shining Google Scholar
[2]
a spotlight on maternal and neonatal sepsis: Google Scholar
[3]
World Sepsis Day, 2017, < http://www.who. Google Scholar
[4]
int/reproductivehealth/topics/maternal perinatal/ Google Scholar
[5]
world-sepsis-day/en/>, accessed: 06/07/2021 Google Scholar
[6]
Pek JH, Yap BJ et al., Neurocognitive impairment Google Scholar
[7]
after neonatal sepsis: protocol for a systematic Google Scholar
[8]
review and meta-analysis. BMJ Open, 10(6), Google Scholar
[9]
, pp.125-132 Google Scholar
[10]
Ng PC, Li G, Chui KM et al., Neutrophil CD64 Google Scholar
[11]
Is a Sensitive Diagnostic Marker for Early-Onset Google Scholar
[12]
Neonatal Infection. Pediatr Res, 56(5), 2004, Google Scholar
[13]
pp.796–803. Google Scholar
[14]
Genel F, Atlihan F, Ozsu E et al., Monocyte HLA208 Google Scholar
[15]
DR expression as predictor of poor outcome in Google Scholar
[16]
neonates with late onset neonatal sepsis. Journal Google Scholar
[17]
of Infection, 60(3), 2010, pp. 224–228. Google Scholar
[18]
Phạm Thị Ngọc Thảo, Nguyễn Lý Minh Duy, Google Scholar
[19]
Đánh giá chỉ số nhiễm khuẩn huyết (tỷ số CD64 Google Scholar
[20]
trên bạch cầu đa nhân trung tính/HLA-DR trên Google Scholar
[21]
bạch cầu đơn nhân) trong nhiễm khuẩn huyết, Google Scholar
[22]
sốc nhiễm khuẩn, Tạp chí Y học Việt Nam, 496, Google Scholar
[23]
, tr.555–563. Google Scholar
[24]
Cai N, Fan W, Tao M et al., A significant Google Scholar
[25]
decrease in hemoglobin concentrations may Google Scholar
[26]
predict occurrence of necrotizing enterocolitis Google Scholar
[27]
in preterm infants with late-onset sepsis. Google Scholar
[28]
Journal of International Medical Research, Google Scholar
[29]
(9), 2020, pp.1–10 Google Scholar
[30]
Thái Bằng Giang, Đặc điểm dịch tễ học lâm sàng Google Scholar
[31]
nhiễm nấm ở trẻ sơ sinh và hiệu quả điều trị dự Google Scholar
[32]
phòng bằng Fluconazole trên trẻ đẻ non, Luận án Google Scholar
[33]
tiến sỹ y học, Đại học Y Hà Nội, 2021. Google Scholar
[34]
Trần Diệu Linh, Một số nhận xét về tình hình Google Scholar
[35]
nhiễm khuẩn sơ sinh sớm ở trẻ đủ tháng tại Trung Google Scholar
[36]
tâm Chăm sóc và Điều trị sơ sinh Bệnh viện Phụ Google Scholar
[37]
Sản Trung ương. Tạp chí Phụ sản, 13(2A), 2015, Google Scholar
[38]
tr.118–121. Google Scholar
[39]
Newman TB, Puopolo KM, Wi S et al., Google Scholar
[40]
Interpreting complete blood counts soon after Google Scholar
[41]
birth in newborns at risk for sepsis; Pediatrics, Google Scholar
[42]
(5), 2010, pp. 903–909. Google Scholar
[43]
Hornik CP, Benjamin DK, Becker KC et al., Use Google Scholar
[44]
of the Complete Blood Cell Count in Late-Onset Google Scholar
[45]
Neonatal Sepsis; Pediatr Infect Dis J, 31(8), Google Scholar
[46]
, pp. 803–807 Google Scholar
[47]
Bệnh viện Nhi Trung ương, Hướng dẫn chẩn Google Scholar
[48]
đoán và điều trị bệnh trẻ em, 2018, Tr.197–204 Google Scholar
[49]
Ree, Isabelle MC, Fustolo-Gunnink, Suzanne Google Scholar
[50]
F et al., Thrombocytopenia in neonatal sepsis: Google Scholar
[51]
Incidence, severity and risk factors, PLOS ONE, Google Scholar
[52]
(10), 2017, pp.112–120 Google Scholar
[53]
Trần Diệu Linh, Vũ Bá Quyết, Nguyễn Thu Yến, Google Scholar
[54]
Nhiễm khuẩn sơ sinh sớm ở trẻ đủ tháng sinh mổ Google Scholar
[55]
tại Bệnh viện Phụ Sản Trung ương; Tạp chí Phụ Google Scholar
[56]
sản, 14(1), 2016, tr.120–124. Google Scholar
[57]
Sorsa A, Epidemiology of Neonatal Sepsis and Google Scholar
[58]
Associated Factors Implicated: Observational Google Scholar
[59]
Study at Neonatal Intensive Care Unit of Arsi Google Scholar
[60]
University Teaching and Referral Hospital, Google Scholar
[61]
South East Ethiopia, Ethiop J Health Sci, 29(3), Google Scholar
[62]
, pp.333–342. Google Scholar