Articles Vol. 64 No. 5 23/08/2023

12. EFFICIENCY TREATMENT OF HYPOTENSION AFTER SPINAL ANESTHESIA WITH PHENYLEPHRINE AND EPHEDRINE IN CAESAREAN SECTION

Bui Dang Minh Tri1,2, Khuu Van Ut3,4, Le Thi Ngoc Tuyet5,6
1 University of Medicine Pham Ngoc Thach
2 Trường Đại học Y khoa Phạm Ngọc Thạch
3 Medical Center of Giong Rieng District, Kien Giang Province
4 Trung tâm Y tế huyện Giồng Riềng tỉnh Kiên Giang
5 University of Medicine and Pharmacy at HCMC
6 Đại học Y dược TP Hồ Chí Minh
Corresponding author: drtribui1@gmail.com
DOI: 10.52163/yhc.v64i5.768
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Keywords
Ephedrine, Phenylephrine, spinal anesthesia, pregnant women.
Abstract

Objectives: To compare the results of treatment of hypotension after spinal anesthesia between Phenylephrine and Ephedrine in women undergoing cesarean section.

Subjects and methods: A prospective, controlled study on 63 women with indications for elective cesarean section under spinal anesthesia treated with Phenylephrine or Ephedrine at Giong Rieng District Health Center from January 2022 to September 2022.

Results: After spinal anesthesia, blood pressure tended to decrease. After taking vasopressors, blood pressure increase was not different between the two groups. Following administration of Phenylephrine resulted in a sharper decrease in heart rate to approximately approximating baseline heart rate, while Ephrine did not alter heart rate significantly and was more stable. Cardiac output was significantly reduced in the phenylephrine group and increased in the ephedrine group. Phenylephrine caused more bradycardia than Ephedrine. Phenylephrine causes nausea and vomiting less than Ephedrine. Phenylephrine caused bradycardia more than Ephedrine, Phenylephrine caused nausea, vomiting less than Ephedrine.

Conclusion: Phenylephrine had a strong reduction in heart rate. Ephrine did not change heart rate significantly. Cardiac output decreased in the phenylephrine group and increased in the ephedrine group.

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