Articles Vol. 64 No. 5 23/08/2023

3. EFFICIENCY OF REDUCING BRAXTON HICKS AND ADVERSE EFFECTS OF NIFEDIPINE IN TREATMENT OF PREMATURE LABOR

Bui Dang Minh Tri1,2, Bui Dang Lan Huong3,4, Nguyen Viet Thanh5,6
1 University of Medicine Pham Ngoc Thach
2 Trường Đại học Y khoa Phạm Ngọc Thạch
3 Tu Du Hospital
4 Bệnh viện Từ Dũ
5 Vinh Long Provincial Eye Hospital
6 Bệnh viện Mắt Tỉnh Vĩnh Long
Corresponding author: drtribui1@gmail.com
DOI: 10.52163/yhc.v64i5.759
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Keywords
Nifedipine, premature labor, effectiveness, side effects.
Abstract

Objectives: To describe the effectiveness of reducing braxton hicks and the adverse effects of nifedipine in treating premature labor.

Subjects and methods: a retrospective descriptive study on 220 pregnant women who came to the emergency department of Obstetrics and Gynecology, Vinh Long Provincial General Hospital, were diagnosed with premature labor from January 1st, 2021 to December 31st, 2021.

Results: The successful rate of prolongation of pregnancy ≥48 h in women with threatened preterm labor between 28 and 34 weeks treated with nifedipine was 70.5% (95% CI 66.6 – 74.0). The cumulative probability of successful treatment was more than 50% when the total treatment dose was at least 5 doses. The average length of gestational age was 21 days. The rate of pregnant women and fetuses with adverse effects of nifedipine during treatment was 6.4%, which often appeared transiently after the loading dose.

Conclusion: The success rate of prolonging pregnancy in women with threatened preterm birth with nifedipine was 70.5%. The incidence of adverse effects in pregnant women and fetuses of nifedipine was usually transient after the loading dose.

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