Articles Vol. 64 No. CD 5 -Nghiên cứu khoa học 24/07/2024

TO STUDY THE EFFECT OF THE TRADITIONAL MEDICINE REMEDY "BO THAN SINH TINH THANG" ON THE CAVERNOSUM PRESSURE OF WHITE MALE RATS

Nguyen Thanh Ha Tuan1,2, Vu Tri Linh1,2, Ngo Thi Khuyen3,4, Dang Duc Nhu5,6
1 Vietnam Military Medical Academy
2 Học viện Quân Y
3 Tue Tinh Institute of Medical and Pharmaceutical Research
4 Viện Nghiên cứu Y Dược học Tuệ Tĩnh
5 University of Medicine and Pharmacy - Vietnam National University, Hanoi
6 Trường Đại học Y dược - Đại học Quốc gia Hà Nội
Corresponding author: dangnhu258@yahoo.com
DOI: 10.52163/yhc.v64i4.712
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Keywords
Bo than sinh tinh thang, intracavernous pressure, male Wistar rats.
Abstract

Objectives: Evaluation of the effect of the traditional medicine remedy «Bo than sinh tinh thang» on
the cavernosum pressure of male Wistar rats.
Method: To study on 40 male Wistar rats 24-week-old oral «Bo than sinh tinh thang» remedy
extract only once, after anesthesia and measured ICP (intracavernous pressure) before taking the
drug. Measurement of ICP, arterial blood pressure by powerlab system before and after stimulating
cavernous nerves at the time before and after taking drugs 15 minutes, 30 minutes, 45 minutes.
Results: “Bo than sinh tinh thang” increased basal ICP at 30 minutes and 45 minutes after taking
drugs (p <0.05); increases ICP max, response time and ICP max/MAP (p <0.01) after electrical
stimulation on the cavernous nerve at 15 minutes, 30 minutes and 45 minutes after taking drugs
compared with before taking drugs as well as the control, but did not affect mean arterial pressure in
rats. The effects of this remedy were equivalent to a Sildenafil dose of 10 mg/kg.
Conclusion: “Bo than sinh tinh thang” remedy increase intracavernous pressure on anesthetic Wistar
rats and does not affect arterial blood pressure.

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