Objectives: (1) To describe the prevalence and bothersomeness of menopausal symptoms assessed by the MENQOL-V; (2) to identify factors associated with poor quality of life among menopausal women in Can Tho City. Methods: An analytical cross-sectional study was conducted among 1,600 menopausal women in Can Tho City (December 2024–August 2025). Quality of life was assessed with the 28-item Vietnamese MENQOL (MENQOL-V); poor quality of life was defined as an overall score ≥ 2.09 (the sample’s 75th percentile). Multivariable Poisson regression accounting for the complex sampling design was used to estimate adjusted prevalence ratios (PRs).
Results: The most common symptoms were poor memory (77.1%), aching muscles and joints (69.1%), and difficulty sleeping (61.1%); these symptoms and low backache had a median bothersomeness score of 4.00 (scale 2–8). Each 0.1-unit increase in waist-to-hip ratio was associated with a 12% higher prevalence of poor quality of life (adjusted PR = 1.12; 95% CI: 1.08–1.15). Having no religion, having no chronic disease, fewer years since menopause, and lower attitude and practice scores were also associated with poor quality of life after adjustment.
Conclusions: Menopause care should focus on controlling central obesity, supporting self-care practices, and addressing poor memory, joint pain, sleep difficulty, and low backache.