Articles Tập 67 Số CĐ16 05/11/2026

CLINICAL AND PARACLINICAL CHARACTERISTICS AND COMBINATION TREATMENTS OF PATIENTS AGED 16 YEARS OR OLDER WITH STABLE VITILIGO UNDERGOING AUTOLOGOUS EPIDERMAL CELL TRANSPLANTATION AT THE NATIONAL HOSPITAL OF DERMATOLOGY AND VENEREOLOGY

Do Thi Thuy Hong, Le Huu Doanh, Hoang Van Tam, Ha Tuan Minh, Vu Thi Dung, Nguyen Thi Thu Phuong, Dinh Quoc Tuan, Do Thi Thu Hien
DOI: 10.52163/yhc.v67iCD16.6994
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Abstract

Objective: To describe the clinical and paraclinical characteristics of patients aged 16 years or older with stable vitiligo undergoing autologous epidermal cell transplantation at the National Hospital of Dermatology and Venereology from November 2024 to May 2026 and the combination treatments used.

Methods: A descriptive cross-sectional study with retrospective and prospective data collection was conducted among 90 patients aged 16 years or older who underwent non-cultured autologous epidermal cell transplantation. Quantitative variables were summarized using mean ± standard deviation or median and interquartile range; categorical variables were summarized as frequencies and percentages.

Results: The mean age was 29.6 ± 10.5 years and women accounted for 54.4%. Segmental vitiligo was present in 77.8%, and the face was the most common recipient site. Six patients underwent a second transplantation. After transplantation, 15 patients received phototherapy, 20 received both phototherapy and topical treatment, 30 used moisturizer alone, and 30 received topical tacrolimus.

Conclusion: Patients selected for autologous epidermal cell transplantation were predominantly young, had segmental vitiligo, and commonly had facial lesions. Post-transplantation management involved several topical and phototherapy-based approaches, used alone or in combination.

Keywords
stable vitiligo; autologous epidermal cell transplantation; clinical characteristics; paraclinical characteristics; combination treatment.
References
[1]
1. Parsad D, Dogra S, Kanwar AJ. Quality of life in patients with vitiligo. Health Qual Life Outcomes. 2003;1:58. doi:10.1186/1477-7525-1-58. Google Scholar
[2]
2. Eleftheriadou V, Atkar R, Batchelor J, et al. British Association of Dermatologists guidelines for the management of people with vitiligo 2021. Br J Dermatol. 2022;186(1):18–29. doi:10.1111/bjd.20596. Google Scholar
[3]
3. Seneschal J, Speeckaert R, Taïeb A, et al. Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations. J Eur Acad Dermatol Venereol. 2023;37(11):2185–2195. doi:10.1111/jdv.19450. Google Scholar
[4]
4. Mulekar SV. Long-term follow-up study of segmental and focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation. Arch Dermatol. 2004;140(10):1211–1215. doi:10.1001/archderm.140.10.1211. Google Scholar
[5]
5. Toossi P, Shahidi-Dadras M, Mahmoudi Rad M, Fesharaki RJ. Non-cultured melanocyte-keratinocyte transplantation for the treatment of vitiligo: a clinical trial in an Iranian population. J Eur Acad Dermatol Venereol. 2011;25(10):1182–1186. doi:10.1111/j.1468-3083.2010.03946.x. Google Scholar
[6]
6. Ezzedine K, Lim HW, Suzuki T, et al. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012;25(3):E1–E13. doi:10.1111/j.1755-148X.2012.00997.x. Google Scholar
[7]
7. Zhang D, Wei X, Hong W, Fu L, Qian G, Xu AE. A retrospective study of long term follow-up of 2283 vitiligo patients treated by autologous, non-cultured melanocyte-keratinocyte transplantation. Aging (Albany NY). 2021;13(4):5415–5425. doi:10.18632/aging.202472. Google Scholar
[8]
8. Cavalié M, Ezzedine K, Fontas E, et al. Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. J Invest Dermatol. 2015;135(4):970–974. doi:10.1038/jid.2014.527. Google Scholar
[9]
9. Chen C, Yu N, Liu Z, Tao Y, Liu B. New pigmentation after medical treatment suggests increased efficacy of dermabrasion and noncultured epidermal cell suspension techniques in stable vitiligo. Dermatol Surg. 2021;47(4):e142–e145. doi:10.1097/DSS.0000000000002820. Google Scholar
[10]
10. Hasan MS, Almohsen AM, Nasr MI, Rageh MA. Dermabrasion versus microneedling in transplantation of autologous noncultured melanocyte-keratinocyte cell suspension in patients with vitiligo. Dermatol Surg. 2023;49(5):494–502. doi:10.1097/DSS.0000000000003738. Google Scholar