Articles Vol. 67 No. 10 04/11/2026

CLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH DIABETES MELLITUS COMPLICATED BY DIABETIC KETOACIDOSIS TREATED AT BACH MAI HOSPITAL

Vu Tuan Minh, Nguyen Quang Bay
DOI: 10.52163/yhc.v67i10.6982
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Abstract

Objective: To describe the clinical and laboratory characteristics of patients with diabetic ketoacidosis treated at Bach Mai Hospital.

Subjects and methods: A prospective descriptive study was conducted in 55 patients with diabetes mellitus complicated by diabetic ketoacidosis who were treated at Bach Mai Hospital between September 2025 and June 2026.

Results: The mean age of the patients was 46.6 ± 19.5 years. Females accounted for a higher proportion than males (58.2% vs. 41.8%), and patients aged ≥ 60 years represented the largest age group (34.5%). Newly diagnosed diabetes mellitus was identified in 36.4% of patients, while 65.7% had a history of poor treatment adherence. Symptoms of hyperglycaemia (81.8%) and metabolic acidosis (72.7%) were the most common clinical manifestations. The mean HbA1c level was 10.96 ± 3.01%, and the mean blood glucose concentration was 30.12 ± 13.17 mmol/L. Most patients presented with severe metabolic acidosis at admission, with serum bicarbonate (HCO₃-) levels < 10 mmol/L (72.7%).

Conclusions: Diabetic ketoacidosis at Bach Mai Hospital was more frequently observed in females, older adults, and patients with newly diagnosed diabetes or poor glycaemic control. The condition was characterised by marked hyperglycaemia and severe metabolic acidosis at the time of hospital admission.

References
[1]
[1] Magliano D.J, Boyko E.J and Diabetes Atlas 11th Edition Scientific Committee. IDF Diabetes Atlas, 11th ed. International Diabetes Federation, Brussels (Belgium), 2025. Google Scholar
[2]
[2] Zewdu B et al. Incidence and determinants of diabetic ketoacidosis among people with diabetes in Woldiya Comprehensive Specialized Hospital, Ethiopia: a retrospective cohort study. BMC Endocrine Disorders, 2024, 24 (1): 34. doi: 10.1186/s12902-024-01552-1. Google Scholar
[3]
[3] Dhatariya K.K et al. Diabetic ketoacidosis. Nature Reviews Disease Primers, 2020, 6 (1): 40. doi: 10.1038/s41572-020-0165-1. Google Scholar
[4]
[4] Umpierrez G.E et al. Hyperglycemic crises in adults with diabetes: a consensus report. Diabetologia, 2024, 67 (8):1455-1479. doi: 10.1007/s00125-024-06183-8. Google Scholar
[5]
[5] Dhatariya K.K, JBDSfI Care. The management of diabetic ketoacidosis in adults - An updated guideline from the Joint British Diabetes Society for Inpatient Care. Diabetic Medicine, 2022, 39 (6): e14788. doi: 10.1111/dme.14788. Google Scholar
[6]
[6] Athar A et al. Determinants of diabetic ketoacidosis severity and clinical characteristics of DKA: a retrospective audit in a metropolitan ICU in Australia. The Journal of Health Design, 2025, 10 (1): 699-706. doi: 10.21853/JHD.2025.239 Google Scholar
[7]
[7] Nguyễn Minh Tuấn Anh, Nguyễn Khoa Diệu Vân. Mô tả đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân đái tháo đường có biến chứng cấp tính (nhiễm toan ceton và/hoặc tăng áp lực thẩm thấu). Tạp chí Y học Việt Nam, 2023, 533 (1): 161-165. doi: 10.51298/vmj.v533i1.7734 Google Scholar
[8]
[8] Lưu Ngọc Trân và cộng sự. Nghiên cứu tỷ lệ và kết quả điều trị nhiễm toan ceton ở bệnh nhân đái tháo đường tại Bệnh viện Đa khoa thành phố Cần Thơ năm 2023. Tạp chí Y học Việt Nam, 2024, 544 (1): 208-212. doi: 10.51298/vmj.v544i1.11733 Google Scholar
[9]
[9] Lê Phúc Trường Thịnh. Đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị bệnh nhân nhiễm toan ceton đái tháo đường tại Khoa Hồi sức tích cực - Chống độc, Bệnh viện Đa khoa Trung tâm Tiền Giang. Tạp chí Nội tiết và Đái tháo đường, 2024, 56: 37-43. doi: 10.47122/vjde.2022.56.5 Google Scholar
[10]
[10] Atiase Y et al. Clinical characteristics and severity of diabetic ketoacidosis: a cross-sectional study from a tertiary hospital in Ghana. Tropical Medicine & International Health, 2023, 28 (9): 790-796. doi: 10.1111/tmi.13919. Google Scholar