Articles Tập 67 Số CĐ16 02/11/2026

PHÌNH ĐỘNG MẠCH VÀNH TẠI ĐIỂM PHÂN BA THÂN CHUNG ĐỘNG MẠCH VÀNH TRÁI: BÁO CÁO CA LÂM SÀNG

Nguyen Phuong Thao, Pham Manh Chung, Trinh Van Dong, Pham Van Tung, Dinh Hong Thanh, Phan Le Kim Chi
DOI: 10.52163/yhc.v67iCD16.6942
0 Views
0 Downloads
Abstract

Background: Coronary artery aneurysm is a rare clinical entity, often incidentally detected during coronary angiography. In elderly patients, pathogenesis is primarily linked to chronic atherosclerosis, which leads to the destruction of the tunica media and maladaptive arterial remodeling.

Case presentation: A 70-year-old man with a medical history of hypertension and dyslipidemia presented with a 1-week history of exertional left-sided chest pain radiating to the neck, which was relieved by rest. On admission, electrocardiography showed no significant ST-segment or T-wave changes. High-sensitivity cardiac troponin T (hs-cTnT; upper reference limit, 14 ng/L) was not elevated at either 0 or 3 hours, with levels of 7 and 7.62 ng/L, respectively. Transthoracic echocardiography revealed no regional wall-motion abnormalities.

Coronary computed tomography angiography (CCTA) showed a localized fusiform aneurysm of the distal left main coronary artery (LMCA), measuring 16 mm in length and 9 mm in maximal diameter, at the trifurcation into the left anterior descending artery (LAD), left circumflex artery (LCx), and ramus intermedius. The Agatston coronary artery calcium score was 315. In addition, a 45% atherosclerotic stenosis was identified in the first diagonal branch (D1).

Management: The patient was diagnosed with stable angina associated with a coronary artery aneurysm, most likely of atherosclerotic etiology. He was managed with optimal medical therapy for symptom control, along with strict blood pressure and lipid management, targeting an LDL-cholesterol level of <1.8 mmol/L. After 28 months of follow-up, the size of the coronary aneurysm remained stable, with good control of anginal symptoms, blood pressure, and lipid levels. No acute cardiovascular events were documented during the follow-up period.

Conclusion: This case suggests that, in patients with a fusiform coronary artery aneurysm presenting with stable clinical symptoms, optimal medical therapy combined with regular imaging surveillance may be considered to control cardiovascular risk factors and monitor the stability of the aneurysmal vessel.

References
[1]
[1] Abou Sherif, S., Ozden Tok, O., Taşköylü, Ö., Goktekin, O., & Kilic, I. D. (2017). Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treatment. Frontiers in Cardiovascular Medicine, 4. https://doi.org/10.3389/fcvm.2017.00024 Google Scholar
[2]
[2] Aqel, R. A., Zoghbi, G. J., & Iskandrian, A. (2004). Spontaneous Coronary Artery Dissection, Aneurysms, and Pseudoaneurysms: A Review. Echocardiography, 21(2), 175–182. https://doi.org/10.1111/j.0742-2822.2004.03050.x Google Scholar
[3]
[3] Befeler, B., Aranda, J. M., Embi, A., Mullin, F. L., El-Sherif, N., & Lazzara, R. (1977). Coronary artery aneurysms: Study of their etiology, clinical course and effect on left ventricular function and prognosis. The American Journal of Medicine, Symposium on Drug Action and Metabolism in Renal Failure, 62(4), 597–607. https://doi.org/10.1016/0002-9343(77)90423-5 Google Scholar
[4]
[4] Crawley, P. D., Mahlow, W. J., Huntsinger, D. R., Afiniwala, S., & Wortham, D. C. (2014). Giant Coronary Artery Aneurysms: Review and Update. https://doi.org/10.14503/THIJ-13-3896 Google Scholar
[5]
[5] Díaz-Zamudio, M., Bacilio-Pérez, U., Herrera-Zarza, M. C., Meave-González, A., Alexanderson-Rosas, E., Zambrana-Balta, G. F., & Kimura-Hayama, E. T. (2009). Coronary Artery Aneurysms and Ectasia: Role of Coronary CT Angiography. RadioGraphics, 29(7), 1939–1954. https://doi.org/10.1148/rg.297095048 Google Scholar
[6]
[6] Eshtehardi, P., Cook, S., Moarof, I., Triller, H.-J., & Windecker, S. (2008). Giant Coronary Artery Aneurysm. Circulation: Cardiovascular Interventions, 1(1), 85–86. https://doi.org/10.1161/CIRCINTERVENTIONS.107.763656 Google Scholar
[7]
[7] Güvenç, R. Ç., Al Arfaj, A. A., Razouk, H., & Güvenç, T. S. (2025). Pathophysiology, Diagnosis, and Management of Coronary Artery Aneurysms: A Review. Reviews in Cardiovascular Medicine, 26(8), 39702. https://doi.org/10.31083/RCM39702 Google Scholar
[8]
[8] Jha, N. K., Ouda, H. Z., Khan, J. A., Eising, G. P., & Augustin, N. (2009). Giant right coronary artery aneurysm- case report and literature review. Journal of Cardiothoracic Surgery, 4, 18. https://doi.org/10.1186/1749-8090-4-18 Google Scholar
[9]
[9] Manginas, A., & Cokkinos, D. V. (2006). Coronary artery ectasias: Imaging, functional assessment and clinical implications. European Heart Journal, 27(9), 1026–1031. https://doi.org/10.1093/eurheartj/ehi725 Google Scholar
[10]
[10] Morita, H., Ozawa, H., Yamazaki, S., Yamauchi, Y., Tsuji, M., Katsumata, T., & Ishizaka, N. (2012). A case of giant coronary artery aneurysm with fistulous connection to the pulmonary artery: A case report and review of the literature. Internal Medicine, 51(11), 1361–1366. https://doi.org/10.2169/internalmedicine.51.7134 Google Scholar
[11]
[11] Nichols, L., Lagana, S., & Parwani, A. (2008). Coronary artery aneurysm: A review and hypothesis regarding etiology. Archives of Pathology & Laboratory Medicine, 132(5), 823–828. https://doi.org/10.5858/2008-132-823-CAAARA Google Scholar
[12]
[12] Núñez-Gil, I. J., Terol, B., Feltes, G., Nombela-Franco, L., Salinas, P., Escaned, J., Jiménez-Quevedo, P., Gonzalo, N., Vivas, D., Bautista, D., Macaya, C., & Fernández-Ortiz, A. (2018). Coronary aneurysms in the acute patient: Incidence, characterization and long-term management results. Cardiovascular Revascularization Medicine, 19(5, Part B), 589–596. https://doi.org/10.1016/j.carrev.2017.12.003 Google Scholar
[13]
[13] Pahlavan, P. S., & Niroomand, F. (2006). Coronary artery aneurysm: A review. Clinical Cardiology, 29(10), 439–443. https://doi.org/10.1002/clc.4960291005 Google Scholar
[14]
[14] Sánchez-Sánchez, I., Cerrato, E., Bollati, M., Espejo-Paeres, C., Nombela-Franco, L., Alfonso-Rodríguez, E., Camacho-Freire, S. J., Villablanca, P. A., Amat-Santos, I. J., De la Torre Hernández, J. M., Pascual, I., Liebetrau, C., Camacho, B., Pavani, M., Albistur, J., Latini, R. A., Varbella, F., Jiménez Díaz, V. A., Piraino, D., … CAAR Investigators. (2024). Long-Term Prognosis of Coronary Aneurysms. JACC: Cardiovascular Interventions, 17(22), 2681–2691. https://doi.org/10.1016/j.jcin.2024.08.034 Google Scholar
[15]
[15] Sannino, M., Nicolai, M., Infusino, F., Giulio, L., Usai, T. L., Biscotti, G., Azzarri, A., D’Ossat, M. D. A., Calcagno, S., & Calcagno, S. (2024). Coronary Artery Aneurysms: A Clinical Case Report and Literature Review Supporting Therapeutic Choices. Journal of Clinical Medicine, 13(18). https://doi.org/10.3390/jcm13185348 Google Scholar
[16]
[16] Ten Kate, G. J. R., Weustink, A. C., & de Feyter, P. J. (2008). Coronary artery anomalies detected by MSCT-coronary angiography in the adult. Netherlands Heart Journal: Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 16(11), 369–375. https://doi.org/10.1007/BF03086181 Google Scholar
[17]
[17] Torres, R. J., & Changlani, M. (2017). Coronary artery aneurysms in the elderly: Case report. Interventional Cardiology, 9(5), 211–214. https://doi.org/10.4172/Interventional-Cardiology.1000581 Google Scholar