Articles Tập 67 Số CĐ16 02/11/2026

PROGNOSTIC VALUE OF RED BLOOD CELL DISTRIBUTION WIDTH IN PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA

Ha Van Quang, Pham The Duc, Le Thi Tam Thao
DOI: 10.52163/yhc.v67iCD16.6940
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Abstract

Objective: This study aimed to assess the prognostic significance of RDW in relation to clinical outcomes in patients with diffuse large B-cell lymphoma (DLBCL).

Subjects and Methods: A total of 134 patients diagnosed and treated at Military Hospital 103 between January 2016 and January 2026 were included. Patients were stratified into two groups using an RDW cutoff value of 14%.

Results: Patients with RDW >14% showed significantly higher proportions of ECOG ≥2, Ann Arbor stage (III/IV), elevated β₂-microglobulin levels, and high-risk R-IPI classification compared with those with RDW ≤14% (p <0.05). The non-response rate to treatment was also higher in the RDW >14% group than in the RDW ≤14% group (24.2% vs. 9.7%; p =0.023). A significant reduction in median RDW after chemotherapy was observed among patients achieving complete response (p =0.041). An RDW value greater than 14% was associated with a 1.695-fold increase in the risk of disease progression and a 1.876-fold increase in the risk of mortality. Furthermore, the 3-year PFS and OS rates in the RDW >14% group (46.8% and 54.8%, respectively) were significantly lower than those in the RDW ≤14% group (63.9% and 75.0%; p <0.01).

Conclusions: Overall, RDW was closely correlated with treatment response, PFS and OS in patients with DLBCL.

Keywords
Diffuse large B-cell lymphoma, red blood cell distribution width, Revised International Prognostic Index
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