Articles Tập 67 Số CĐ16 02/11/2026

CHARACTERISTICS OF SELECTED CO-DETECTED MICROORGANISMS IN CHILDREN WITH INFLUENZA A TREATED AT THE PEDIATRIC CENTER, THAI NGUYEN NATIONAL HOSPITAL

Nguyen Huu Nghia, Nguyen Bich Hoang, Pham Tien Thinh, Nguyen Thi Thu Minh, Le Thi Kim Dung
DOI: 10.52163/yhc.v67iCD16.6932
4 Views
0 Downloads
Abstract

Objective: To describe selected microorganisms co-detected in children with influenza A treated at the Pediatric Center, Thai Nguyen National Hospital.

Subjects and Methods: A cross-sectional descriptive study included 170 hospitalized children aged 1 month to 15 years with confirmed influenza A at the Pediatric Center, Thai Nguyen National Hospital, from January 2025 to June 2026.

Results: Children aged 24–59 months accounted for 34.1%, males for 64.7%, and 92.4% of admissions occurred from October through March. At least one additional microorganism was detected in 44.7%; bacterial and viral detections were 41.2% and 6.5%, respectively. S. pneumoniae was detected most often among bacterial-positive children (57.1%), and RSV among viral-positive children (72.7%). In unadjusted exploratory comparisons, bacterial detection proportions differed by age group, admission period, and recorded pneumococcal or Hib vaccination status (p<0.05). Vaccination records did not include dose number or age-appropriate completion.

Conclusion: Additional microorganisms were detected in hospitalized children with influenza A, predominantly bacteria. Findings from unadjusted exploratory comparisons should not be interpreted as independent risk factors or vaccine effectiveness.

References
[1]
[1] World Health Organization. Clinical practice guidelines for influenza. Geneva: World Health Organization; 2024. Available from: https://www.who.int/publications/i/item/9789240097759. Google Scholar
[2]
[2] Dawood FS, Chaves SS, Pérez A, Reingold A, Meek J, Farley MM, et al. Complications and associated bacterial coinfections among children hospitalized with seasonal or pandemic influenza, United States, 2003-2010. J Infect Dis. 2014;209(5):686-694. doi:10.1093/infdis/jit473. Google Scholar
[3]
[3] Bộ Y tế. Quyết định số 1840/QĐ-BYT ngày 03/6/2025 về việc ban hành tài liệu chuyên môn “Hướng dẫn chẩn đoán và điều trị cúm mùa”. Hà Nội: Bộ Y tế; 2025. Google Scholar
[4]
[4] Morris DE, Cleary DW, Clarke SC. Secondary bacterial infections associated with influenza pandemics. Front Microbiol. 2017;8:1041. doi:10.3389/fmicb.2017.01041. Google Scholar
[5]
[5] Meskill SD, Revell PA, Chandramohan L, Cruz AT. Prevalence of co-infection between respiratory syncytial virus and influenza in children. Am J Emerg Med. 2017;35(3):495-498. doi:10.1016/j.ajem.2016.12.001. Google Scholar
[6]
[6] Trịnh Thị Hiền, Trần Thanh Tú, Nguyễn Thị Bích Hạnh, Nguyễn Thị Huyền Sâm, Nguyễn Huy Khánh, Nguyễn Tân Hùng, và cs. Đặc điểm lâm sàng, cận lâm sàng của bệnh nhân cúm A có đồng nhiễm vi khuẩn tại Trung tâm Quốc tế Bệnh viện Nhi Trung ương. Tạp chí Nhi khoa. 2024;17(4). doi:10.52724/tcnk.v17i4.346. Google Scholar
[7]
[7] Caini S, Andrade W, Badur S, Balmaseda A, Barakat A, Bella A, et al. Temporal patterns of influenza A and B in tropical and temperate countries: what are the lessons for influenza vaccination? PLoS One. 2016;11(3):e0152310. doi:10.1371/journal.pone.0152310. Google Scholar
[8]
[8] McCullers JA. The co-pathogenesis of influenza viruses with bacteria in the lung. Nat Rev Microbiol. 2014;12(4):252-262. doi:10.1038/nrmicro3231. Google Scholar
[9]
[9] Jung J, Seo E, Yoo RN, Sung H, Lee J. Clinical significance of viral-bacterial codetection among young children with respiratory tract infections: findings of RSV, influenza, adenoviral infections. Medicine (Baltimore). 2020;99(2):e18504. doi:10.1097/MD.0000000000018504. Google Scholar
[10]
[10] Smith AM, Huber VC. The unexpected impact of vaccines on secondary bacterial infections following influenza. Viral Immunol. 2018;31(2):159-173. doi:10.1089/vim.2017.0138. Google Scholar