Objective: To evaluate factors associated with treatment outcomes of anterior enamel white spot lesions (WSLs) using resin infiltration.
Subjects and Methods: This prospective, uncontrolled interventional study included 33 patients with 61 anterior teeth presenting with white spot lesions treated using the resin infiltration technique at Military Hospital 175 between June 2025 and April 2026. Treatment outcomes were assessed after treatment, and their associations with selected lesion characteristics were analyzed.
Results: The study included 33 patients (61 teeth) with a mean age of 23.79 ± 4.45 years; 81.8% were female. Mild molar-incisor hypomineralization (MIH) was the most common etiology (77.0%). Most lesions were classified as Type I (<1/3 of the tooth surface) (83.6%), while deep and thick lesions accounted for 59.0% and 60.7%, respectively. After treatment, complete resolution was observed in 82.0% of teeth, and the remaining 18.0% showed improvement. Type I lesions were more likely to achieve complete resolution than Type II lesions (OR = 17.9, 95% CI: 3.4–93.8; p < 0.001). All thin lesions achieved complete resolution (p = 0.002), whereas lesion depth was not significantly associated with treatment outcome (p = 0.106).
Conclusion: A high proportion of anterior white spot lesions achieved complete resolution following resin infiltration. Lesion size and lesion thickness were associated with treatment outcome, whereas no statistically significant association was found between lesion depth and treatment outcome.