Background: Chronic kidney disease is a growing concern and requires management from the early stages. Screening and treating complications to prolong survival and improve the quality of life for patients is considered one of the main aims of chronic kidney disease management and treatment. Bone mineral metabolism disorders are common and appear early, increasing the risk of other complications, leading to hospitalization and death from all causes in patients with chronic kidney disease. Many studies, both domestic and international, have been conducted to clarify the relationship between changes in the concentration of serum calcium, phosphorus, PTH, magnesium and chronic kidney disease. However, most studies are mainly conducted on patients receiving maintenance hemodialysis, while this issue needs to be addressed and managed from the early stages of chronic kidney disease.
Objective: To describe calcium, phosphor, parathyroid hormone, magne levels, and to analyze associated factors in patients with chronic kidney disease receiving conservative therapy at Viet Tiep Friendship Hospital during 2025–2026. Methods: A cross-sectional descriptive study was conducted on 119 patients with a confirmed diagnosis of chronic kidney disease receiving conservative treatment at the Department of Nephrology and Urology, Viet Tiep Friendship Hospital, from January 2025 to April 2026. Results: The median blood adjusted total calcium, PTH, and serum magnesium concentrations in the study patients were 2.25 mmol/L, 20.43 pmol/L, and 0.83 mmol/L, respectively. The mean serum phosphorus concentration was 1.39 ± 0.4 mmol/L. The proportion of patients with hypocalcemia was 20.17%; hyperphosphatemia was 44.54%; increased blood PTH was 81,51%; and hypomagnesemia was 57.14%. There were statistically significant differences in blood adjusted total calcium, phosphorus, and PTH concentrations between the stages of chronic kidney disease, but no statistically significant differences were observed in magnesium concentrations between the stages of chronic kidney disease. There was a correlation between blood adjusted total calcium, phosphorus, PTH, and magnesium concentrations with eGFR. Simultaneously, there was also a correlation between blood adjusted total calcium, phosphorus with PTH concentrations. Conclusion: Serum levels of calcium, phosphorus, PTH, and magnesium may change as chronic kidney disease progresses. Calcium and phosphorus levels should be monitored and evaluated according to the stage of chronic kidney disease.