Articles Vol. 67 No. 10 31/10/2026

CLINICAL, PARACLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF IRON DEFICIENCY ANEMIA IN CHILDREN AT NGHE AN OBSTETRICS AND PEDIATRICS HOSPITAL

Nguyen Thi Kieu Oanh, Nguyen Hoang Nam, Nguyen Thi Huong Mai, Nguyen Hoai Nam, Nguyen Thuy Dung
DOI: 10.52163/yhc.v67i10.6907
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Abstract

Objectives: To describe the clinical, subclinical characteristics, and treatment outcomes of iron deficiency anemia (IDA) in children at Nghe An Obstetrics and Pediatrics Hospital.

Methods: This case series included 178 pediatric IDA patients at Nghe An Obstetrics and Pediatrics Hospital (July 2025–May 2026). Overall, 164 children in the nutritional group received treatment, with 105 follow-up patients included in the pre- and post-treatment analysis.

Results: IDA was predominantly observed in children under 5 years old, with the 6–23 months age group accounting for the highest proportion at 64.0%. Regarding etiology, nutritional iron deficiency was the primary cause, accounting for 92.1%, while blood loss represented a minor proportion of 7.9% (gastrointestinal bleeding: 7.3%, menorrhagia: 0.6%). The most common clinical signs were pallor (95.5%) and pale mucous membranes (70.2%). Other non-specific symptoms such as lusterless/ridged nails, angular cheilitis, and eating non-food items were rare, with rates of 5.6%, 5.6%, and 1.1%, respectively. Subclinically, microcytic anemia was the predominant type, accounting for 92.7%, while normocytic anemia was less common 7.3%. After 3 months of oral iron supplementation, 105 children from the nutritional IDA group returned for follow-up, showing significant improvement: 89.5% of the children fully recovered from anemia, 10.5% improved to mild anemia, and no cases of moderate or severe anemia remained.

Conclusions: IDA presented primarily as microcytic anemia with pallor. In 105 follow-up patients, hematological parameters improved after 3 months.

References
[1]
1. Iolascon A, Andolfo I, Russo R, Sanchez M, Busti F, Swinkels D, et al. Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia. Hemasphere. 2024;8(7):e108. Google Scholar
[2]
2. Jogu P, Kamran MT. Iron-Deficiency Anemia(Archived). StatPearls. Treasure Island (FL): StatPearls Publishing LLC.; 2026. Google Scholar
[3]
3. Aksu T, Ünal Ş. Iron Deficiency Anemia in Infancy, Childhood, and Adolescence. Turk Arch Pediatr. 2023;58(4):358-62. Google Scholar
[4]
4. World Health Organization. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva2020. Google Scholar
[5]
5. World Health Organization. Guideline on haemoglobin cutoffs to define anaemia in individuals and populations.2024. Google Scholar
[6]
6. Caroline A. Hastings, Joseph C. Torkidson, Anurag K. Agrawal. Handbook of Pediatric Hematology and Oncology: Children's Hospital and Research Center Oakland, 2nd Edition2016. Google Scholar
[7]
7. World Health Organization. Guideline for complementary feeding of infants and young children 6–23 months of age. 2023. Google Scholar
[8]
8. Nguyễn Thị Trang, Nguyễn Ngọc Sáng, Vũ Văn Quang, Nguyễn Thị Ngọc Thủy. Đặc điểm dịch tễ học lâm sàng và một số yếu tố liên quan đến thiếu máu thiếu sắt ở trẻ từ 6 tháng đến 5 tuổi. Tạp chí Y học Việt Nam. 2021;503(Số đặc biệt):194-9. Google Scholar
[9]
9. Trần Xuân Tuấn, Nguyễn Văn Sơn. Đặc điểm lâm sàng, cận lâm sàng và một số yếu tố liên quan đến thiếu máu thiếu sắt ở bệnh nhân từ 2 tháng đến 60 tháng tại Bệnh viện A Thái Nguyên. Tạp chí Khoa học và Công nghệ Đại học Thái Nguyên. 2022;227(14):22-7, doi: 10.34238/tnu-jst.6268 Google Scholar
[10]
10. Cheng M-M. Iron Deficiency in Young Children Beyond Anemia: Clinical Features, Maternal Factors, and the Predictor for Neuropsychomotor Development Delay. ASH publication. 2023;142. Google Scholar